Optimization of sliding windows IMRT treatment planning

Intensity-modulated radiation therapy (IMRT) with sliding windows is a form of radiation therapy that delivers precise radiation dose to a tumor/target region. It uses a multi-leaf collimator (MLC) to move pairs of unidirectional tungsten leaves across a radiation emitting region to conform the shap...

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Bibliographic Details
Published in:IISE transactions on healthcare systems engineering 2022-08, Vol.12 (3), p.180-192
Main Authors: Habib, Rafiq R., Yeung, Jessie, Darko, Johnson, Osei, Ernest, Mahmoudzadeh, Houra
Format: Article
Language:English
Subjects:
Collimators
dose-volume histogram
Linear programming
optimization
Optimization models
Radiation dosage
Radiation therapy
Sliding
sliding windows IMRT
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Summary:Intensity-modulated radiation therapy (IMRT) with sliding windows is a form of radiation therapy that delivers precise radiation dose to a tumor/target region. It uses a multi-leaf collimator (MLC) to move pairs of unidirectional tungsten leaves across a radiation emitting region to conform the shape of the radiation beam to the target regions. This is a dynamic treatment approach which aims to deliver adequate radiation dose to target regions while minimizing radiation delivery to healthy tissues. This paper proposes a linear optimization model for IMRT with sliding windows. This model directly incorporates a number of deliverability constraints to conform to physical limitations of the LINAC, including the required distance between leaves through the treatment process and restrictions on leaf interdigitation. We demonstrate the viability of this model using patient data and discuss the leaf motion proposed by our model. Such a model can be embedded in treatment planning systems to improve both the quality of the treatment and the efficiency of the treatment planning process.
ISSN:2472-5579
2472-5587
DOI:10.1080/24725579.2022.2027051