A sequence of acylamination and acylation reactions in polyphosphoric acid – a novel approach to the Friedländer synthesis of 2-arylquinolines

A method for the synthesis of 2-(2-acylaminoaryl)quinolines was developed based on a one-pot sequence of direct electrophilic acylamination of arenes with nitroalkanes in polyphosphoric acid and acylation at the ortho position with respect to the acylamino group.

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Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2022-07, Vol.58 (6-7), p.313-318
Main Authors: Grishin, Igor Yu, Malyuga, Vladimir V., Aksenov, Dmitrii А., Kirilov, Nikita K., Abakarov, Gasan M., Ovcharov, Sergei N., Sarapii, Andrei V., Aksenov, Nikolai А., Aksenov, Alexander V.
Format: Article
Language:English
Subjects:
Acylation
Alkaloids
Aromatic compounds
Chemistry
Chemistry and Materials Science
Organic Chemistry
Organic compounds
Pharmacy
Quinoline
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Description
Summary:A method for the synthesis of 2-(2-acylaminoaryl)quinolines was developed based on a one-pot sequence of direct electrophilic acylamination of arenes with nitroalkanes in polyphosphoric acid and acylation at the ortho position with respect to the acylamino group.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-022-03090-x