Rapid One-Pot Multicomponent Dioxane-HCl Complex Catalyzed Solvent-Free Synthesis of 3,4-Dihydropyrimidine-2-One Derivatives

A simple and efficient one-pot multicomponent solvent-free protocol developed for the synthesis of 3,4-dihydropyrimidine-2-one derivatives from the reaction of various aromatic aldehyde, ethyl acetoacetate, urea, and dioxane-HCl as a catalyst. The main advantages of this protocol are solvent-free, a...

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Bibliographic Details
Published in:Polycyclic aromatic compounds 2022-07, Vol.42 (6), p.3865-3873
Main Authors: Choudhare, Tukaram S., Wagare, Devendra S., Kadam, Vijay T., Kharpe, Ajit A., Netankar, Prashant D.
Format: Article
Language:English
Subjects:
3,4-dihydropyrimidine-2-one
Aldehydes
Atom economy
Catalysts
Chemical synthesis
Dioxane-HCl complex
MCRs
solvent-free
Solvents
Urea
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Summary:A simple and efficient one-pot multicomponent solvent-free protocol developed for the synthesis of 3,4-dihydropyrimidine-2-one derivatives from the reaction of various aromatic aldehyde, ethyl acetoacetate, urea, and dioxane-HCl as a catalyst. The main advantages of this protocol are solvent-free, atom economy, inexpensive, excellent product yield, and use of Dioxane-HCl complex as a catalyst.
ISSN:1040-6638
1563-5333
DOI:10.1080/10406638.2021.1873808