Acute and sub-chronic toxicity studies of aqueous bark extract of Detarium microcarpum guill. and perr in albinos wistar rat

Objective This work aimed to evaluate the acute and sub-chronic toxicity of the aqueous bark extract of Detarium microcarpum ( D. microcarpum ), administered orally to rats. Materials and methods An acute (2000 mg/kg) and sub-acute (1000 mg/kg) toxicity studies were conducted following OECD guidelin...

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Bibliographic Details
Published in:Toxicology and environmental health sciences 2022-09, Vol.14 (3), p.269-276
Main Authors: Fotso, Janvier Aimé Youovop, Takuissu, Guy Roussel Nguemto, Ngondi, Judith Laure, Oben, Julius Enyong
Format: Article
Language:English
Subjects:
Acute toxicity
Bark
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cholesterol
Chronic toxicity
Detarium microcarpum
Environmental Health
Hematocrit
Hematology
Leukocytes (granulocytic)
Lymphocytes
Oral administration
Original Article
Parameters
Pharmacology/Toxicology
Plant extracts
Toxicity
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Summary:Objective This work aimed to evaluate the acute and sub-chronic toxicity of the aqueous bark extract of Detarium microcarpum ( D. microcarpum ), administered orally to rats. Materials and methods An acute (2000 mg/kg) and sub-acute (1000 mg/kg) toxicity studies were conducted following OECD guidelines of 425 and 407 respectively. During these studies, general signs of toxicity were observed. The rats used in sub-chronic toxicity were sacrificed, and histological, hematological, and biochemical analyses were done. Results No behavioral changes were observed in all rats. The extract did not bring about any deaths after 14 days at 2000 mg/Kg (acute toxicity) and 28 days at 1000 mg/Kg (sub-acute toxicity) days. Although a significant variation was observed in hematocrit, granulocyte, lymphocyte, ALAT, and total cholesterol levels, the extract had no significant effect ( p < 0.05) on the other biochemical and hematological parameters evaluated. Conclusion The aqueous bark extract of D. microcarpum administered at the repeated dose affected some biochemical and hematological parameters. We can therefore deduce that the extract has lower toxicity (LD 50 ˃ 2000 mg/kg)
ISSN:2005-9752
2233-7784
DOI:10.1007/s13530-022-00139-4