Phytochemicals targeting NF-kB signaling: Potential anti-cancer interventions

Nuclear factor κB (NF-κB) is a ubiquitous regulator of the signalome and is indispensable for various biological cell functions. NF-κB consists of five transcription factors that execute both cytoplasmic and nuclear signaling processes in cells. NF-κB is the only signaling molecule that governs both...

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Bibliographic Details
Published in:Journal of pharmaceutical analysis 2022-06, Vol.12 (3), p.394-405
Main Authors: Chauhan, Akansha, Ul Islam, Asim, Prakash, Hridayesh, Singh, Sandhya
Format: Article
Language:English
Subjects:
Ablation
Apoptosis
Cancer
Cell survival
Chemoresistance
Cytokines
Cytoplasm
Gene expression
Homeostasis
Hyperplasia
Inflammation
Kinases
Liver
Metastases
Metastasis
NF-κB protein
Nuclear transport
Pharmacophores
Phosphorylation
Phytochemicals
Proteins
Signal transduction
Therapeutic targets
Transcription factors
Tumor cells
Tumor necrosis factor-TNF
Tumors
Ubiquitination
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Summary:Nuclear factor κB (NF-κB) is a ubiquitous regulator of the signalome and is indispensable for various biological cell functions. NF-κB consists of five transcription factors that execute both cytoplasmic and nuclear signaling processes in cells. NF-κB is the only signaling molecule that governs both pro- and anti-apoptotic, and pro- and anti-inflammatory responses. This is due to the canonical and non-canonical components of the NF-κB signaling pathway. Together, these pathways orchestrate cancer-related inflammation, hyperplasia, neoplasia, and metastasis. Non-canonical NF-κB pathways are particularly involved in the chemoresistance of cancer cells. In view of its pivotal role in cancer progression, NF-κB represents a potentially significant therapeutic target for modifying tumor cell behavior. Several phytochemicals are known to modulate NF-κB pathways through the stabilization of its inhibitor, IκB, by inhibiting phosphorylation and ubiquitination thereof. Several natural pharmacophores are known to inhibit the nuclear translocation of NF-κB and associated pro-inflammatory responses and cell survival pathways. In view of this and the high degree of specificity exhibited by various phytochemicals for the NF-κB component, we herein present an in-depth overview of these phytochemicals and discuss their mode of interaction with the NF-κB signaling pathways for controlling the fate of tumor cells for cancer-directed interventions.
ISSN:2095-1779
2214-0883
DOI:10.1016/j.jpha.2021.07.002