The hospitalization rate of cerebral venous sinus thrombosis before and during COVID-19 pandemic era: A single-center retrospective cohort study

Background There are several reports of the association between SARS-CoV-2infection (COVID-19) and cerebral venous sinus thrombosis (CVST). In this study, we aimed to compare the hospitalization rate of CVST before and during the COVID-19 pandemic (before vaccination program). Methods In this retros...

Full description

Saved in:
Bibliographic Details
Published in:Journal Of Stroke And Cerebrovascular Diseases 2022
Main Authors: Gharamaleki, Maryam Vasaghi, Habibagahi, Maryam, Hooshmandi, Etrat, Tabrizi, Reza, Arsang-Jang, Shahram, Barzegar, Zohreh, Fadakar, Nima, Ostovan, Vahid Reza, Rahimi-Jaberi, Abbas, Ashjazadeh, Nahid, Petramfar, Peyman, Poursadeghfard, Maryam, Izadi, Sadegh, Nazeri, Masoumeh, Bazrafshan, Hanieh, Bahrami, Zahra, Karimlu, Sadigheh, Seyedeh Shaghayegh Zafarmand, Bayat, Mahnaz, Mohammad Saied Salehi, Owjfard, Maryam, Saeideh Karimi Haghighi, Safari, Anahid, Beng Lim Alvin Chew, Worrall, Bradford B, Coutinho, Jonathan M, Carlos Garcia Esperson, Spratt, Neil, Levi, Christopher, Azarpazhooh, Mahmoud Reza, Borhani-Haghighi, Afshin
Format: Text Resource
Language:English
Subjects:
Cohort analysis
Coronaviruses
COVID-19
Hospitalization
Pandemics
Severe acute respiratory syndrome coronavirus 2
Thrombosis
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background There are several reports of the association between SARS-CoV-2infection (COVID-19) and cerebral venous sinus thrombosis (CVST). In this study, we aimed to compare the hospitalization rate of CVST before and during the COVID-19 pandemic (before vaccination program). Methods In this retrospective cohort study, the hospitalization rate of adult CVST patients in Namazi hospital, a tertiary referral center in the south of Iran, was compared in two periods of time. We defined March 2018 to March 2019 as the pre-COVID-19 period and March 2020 to March 2021 as the COVID-19 period. Results 50 and 77 adult CVST patients were hospitalized in the pre-COVID-19 and COVID-19 periods, respectively. The crude CVST hospitalization rate increased from 14.33 in the pre-COVID-19 period to 21.7 per million in the COVID-19 era (P=0.021). However, after age and sex adjustment, the incremental trend in hospitalization rate was not significant (95% CrI: -2.2, 5.14). Patients > 50-year-old were more often hospitalized in the COVID-19 period. (P=0.042) SARS-CoV-2 PCR test was done in 49.3% out of all COVID-19 period patients, which were positive in 6.5%. Modified Rankin Scale (mRS) score ≥ 3 at three-month follow-up was associated with age (P=0.015) and malignancy (P=0.014) in pre-COVID period; and was associated with age (P=0.025), altered mental status on admission time (P
DOI:10.21203/rs.3.rs-1290632/v1