Association of resveratrol with the suppression of TNF-α/NF-kB/iNOS/HIF-1α axis-mediated fibrosis and systemic hypertension in thioacetamide-induced liver injury

  Chronic liver injury can lead to hepatic failure and the only available method of treatment would be liver transplantation. The link between inflammation (TNF-α), nuclear factor-kappa B (NF-kB), nitrosative stress (iNOS) and hypoxia-inducible factor-1α (HIF-1α) in thioacetamide (TAA) induced liver...

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Published in:Naunyn-Schmiedeberg's archives of pharmacology 2022-09, Vol.395 (9), p.1087-1095
Main Authors: Ebrahim, Hasnaa A., Kamar, Samaa S., Haidara, Mohamed A., Latif, Noha S. Abdel, Ellatif, Mohamed Abd, ShamsEldeen, Asmaa M., Al-Ani, Bahjat, Dawood, Amal F.
Format: Article
Language:English
Subjects:
Actin
Biomarkers
Biomedical and Life Sciences
Biomedicine
Blood pressure
Cholesterol
Fibrosis
Gelatinase B
Heart rate
Hypertension
Hypoxia-inducible factor 1a
Inflammation
Lipoproteins (very low density)
Liver
Liver transplantation
Matrix metalloproteinase
Metalloproteinase
Neurosciences
NF-κB protein
Nitric oxide
Nitric-oxide synthase
Original Article
Pharmacology/Toxicology
Resveratrol
Smooth muscle
Thioacetamide
Triglycerides
Tumor necrosis factor-TNF
Tumor necrosis factor-α
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Summary:  Chronic liver injury can lead to hepatic failure and the only available method of treatment would be liver transplantation. The link between inflammation (TNF-α), nuclear factor-kappa B (NF-kB), nitrosative stress (iNOS) and hypoxia-inducible factor-1α (HIF-1α) in thioacetamide (TAA) induced liver fibrosis, and hypertension with and without the incorporation of the anti-inflammatory and antioxidant resveratrol (RES) has not been investigated before. Consequently, we injected rats with either 200 mg/kg TAA for 8 weeks starting at week 2 (model group) or pretreated them before TAA injections with RES (20 mg/kg) for 2 weeks and continued them on RES and TAA until being culled at week 10 (protective group). In the model group, we documented the induction of hepatic fibrosis and upregulation of tumor necrosis factor-α (TNF-α), NF-kB, inducible nitric oxide synthase (iNOS), HIF-1α and the profibrotic biomarkers alpha-smooth muscle actin (α-SMA) and matrix metalloproteinase-9 (MMP-9) that was significantly ( p  ≤ 0.0014) ameliorated by RES. RES also significantly ( p  ≤ 0.0232) reduced triglycerides (TG), cholesterol (CHOL), very low-density lipoprotein (vLDL-C), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure, and heart rate (HR) induction by TAA. Also, a significant ( p  
ISSN:0028-1298
1432-1912
DOI:10.1007/s00210-022-02264-w