Long-sought mediator of vitamin K recycling

The standard clinical treatment for warfarin poisoning is administration of a high dose of vitamin K, which is reduced to VKH2 by a warfarin-resistant reductase, thereby enabling clotting3. [...]the identity of this 'non-canonical' reductase has been unknown. Fsp1 was necessary to protect...

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Bibliographic Details
Published in:Nature (London) 2022-08, Vol.608 (7924), p.1-2
Main Authors: Ward, Nathan P, DeNicola, Gina M
Format: Article
Language:English
Subjects:
Anticoagulants
Apoptosis
Enzymes
Hemorrhage
Ischemia
Lipids
Phylloquinone
Poisoning
Reductases
Vitamin K
Warfarin
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Summary:The standard clinical treatment for warfarin poisoning is administration of a high dose of vitamin K, which is reduced to VKH2 by a warfarin-resistant reductase, thereby enabling clotting3. [...]the identity of this 'non-canonical' reductase has been unknown. Fsp1 was necessary to protect against lethal brain haemorrhage in mice that had warfarin poisoning and received high-dose vitamin K treatment. [...]warfarin-treated human cells had only a minimal capacity to reduce vitamin K levels if they lacked FSP1. [...]FSP1 is the long-sought mediator of non-canonical vitamin K reduction (Fig. 1b).
ISSN:0028-0836
1476-4687
DOI:10.1038/d41586-022-02001-6