Hepatopancreatoduodenectomy for Locally Advanced Gallbladder Cancer: Is It Worthwhile?

The benefit of hepatopancreatoduodenectomy for locally advanced gallbladder cancer was unclear. An electronic search was conducted in PubMed, Ovid, and the Cochrane Library for the relevant publications reported in the literature between January 1990 and November 2021. Twenty-two studies involving 1...

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Bibliographic Details
Published in:Indian journal of surgery 2022-08, Vol.84 (Suppl 2), p.535-540
Main Authors: Zhou, Yanming, Li, Dianqi, You, Jun, Zeng, Siyuan, Yu, Wenlin
Format: Article
Language:English
Subjects:
Analysis
Cancer
Cardiac Surgery
Database searching
Gallbladder cancer
Health aspects
Internet/Web search services
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Methicillin
Neurosurgery
Online searching
Pediatric Surgery
Plastic Surgery
Prognosis
Review Article
Surgery
Thoracic Surgery
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Summary:The benefit of hepatopancreatoduodenectomy for locally advanced gallbladder cancer was unclear. An electronic search was conducted in PubMed, Ovid, and the Cochrane Library for the relevant publications reported in the literature between January 1990 and November 2021. Twenty-two studies involving 126 patients met the inclusion criteria. Major and minor hepatectomies were performed in 45.6% and 54.4% patients respectively. R0 (microscopically negative margin) resection was achieved in 74.6% patients. The morbidity and 90-day mortality rates were 60.1% and 8.7% respectively. The median overall survival after surgery was 18 months. Multivariate analysis showed that R0 resection was the only independent prognostic factor for survival (hazard ratio 0.115, 95% confidence intervals 0.030–0.445; P  = 0.002). Hepatopancreatoduodenectomy was suggested in patients with locally advanced gallbladder cancer provided that R0 resection can be achieved.
ISSN:0972-2068
0973-9793
DOI:10.1007/s12262-022-03471-8