Safety of Quinolones in Children: A Systematic Review and Meta-Analysis

Background The results of animal experiments show that quinolone antibacterial drugs may permanently damage the soft tissues of the weight-bearing joints of young animals. Out of safety concerns, using quinolones in children has always been controversial. Objective The aim of this study was to asses...

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Bibliographic Details
Published in:Paediatric drugs 2022-09, Vol.24 (5), p.447-464
Main Authors: Li, Siyu, Chen, Zhe, Huang, Liang, Liu, Zheng, Shi, Yuqing, Zhang, Miao, Li, Hailong, Zeng, Linan, Ni, Jiaqi, Zhu, Yu, Jia, Zhi-Jun, Cheng, Guo, Zhang, Lingli
Format: Article
Language:English
Subjects:
Adverse and side effects
Animal research
Animals
Bias
Cartilage
Complications and side effects
Confidence intervals
Drugs
Evaluation
Internal Medicine
International organizations
Medical research
Medicine
Medicine & Public Health
Meta-analysis
Observational studies
Pediatric pharmacology
Pediatrics
Pharmaceuticals
Pharmacology, Experimental
Pharmacotherapy
Quinolones
Systematic Review
Testing
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Summary:Background The results of animal experiments show that quinolone antibacterial drugs may permanently damage the soft tissues of the weight-bearing joints of young animals. Out of safety concerns, using quinolones in children has always been controversial. Objective The aim of this study was to assess the risk of using quinolones in children and provide evidence for clinicians to support decision making. Data Sources The MEDLINE (Ovid), EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), International Pharmaceutical Abstracts (Ovid), CINAHL, CNKI, VIP, and WanFang Data databases were searched from inception to 8 September 2021. Study Selection All types of studies that reported the safety data of quinolones in children, including clinical trials and observational studies. Data Extraction Data extraction and cross-checking were completed by two independent reviewers using a pilot-tested standardized data extraction form. Results The overall incidence rate of adverse drug events (ADEs) in children using systemic quinolones was 5.39% and the most common ADEs were gastrointestinal reactions (incidence rate, 2.02%). Quinolone-induced musculoskeletal ADEs in children were uncommon (0.76%). Meta-analysis results showed that the risk of musculoskeletal ADEs in children using quinolones was higher than children in the control group (51 studies; rate ratio [RR] 2.03, 95% confidence interval [CI] 1.82–2.26; p 
ISSN:1174-5878
1179-2019
DOI:10.1007/s40272-022-00513-2