Breathable and Stretchable Dressings for Accelerating Healing of Infected Wounds

Multidrug‐resistant (MDR) bacteria‐infected wounds are challenging issues that threaten human health. Herein, L‐thioproline (T) and Boc‐capped L‐thioproline (BT)‐decorated gold nanoparticles (TBT‐GNPs) with potent antibacterial activity against MDR bacteria are reported. The TBT‐GNPs are composited...

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Bibliographic Details
Published in:Advanced healthcare materials 2022-09, Vol.11 (17), p.e2201053-n/a
Main Authors: Wang, Le, Zheng, Wenfu, Hou, Qinghong, Zhong, Leni, Li, Qizhen, Jiang, Xingyu
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Antibacterial activity
Bacteria
Bandages
Cellulose
Gas exchange
Gold
gold nanoparticles
Humans
L‐thioproline
Medical dressings
Metal Nanoparticles - therapeutic use
Multidrug resistant organisms
multidrug‐resistant bacteria
Nanoparticles
wound dressing
Wound Healing
Wound Infection - drug therapy
Wound Infection - microbiology
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Summary:Multidrug‐resistant (MDR) bacteria‐infected wounds are challenging issues that threaten human health. Herein, L‐thioproline (T) and Boc‐capped L‐thioproline (BT)‐decorated gold nanoparticles (TBT‐GNPs) with potent antibacterial activity against MDR bacteria are reported. The TBT‐GNPs are composited with bacterial cellulose to form wound dressings which show excellent antimicrobial performance both in vitro and in vivo. Moreover, this dressing is both breathable and stretchable which is favorable for gas exchange to accelerate the wound healing. This work is insightful for developing multifunctional dressings to satisfy the clinical requirements. A wound dressing compositing L‐thioproline and Boc‐capped L‐thioproline‐decorated gold nanoparticles and bacterial cellulose is reported, which shows excellent antimicrobial performance against multidrug‐resistant bacteria. Moreover, this dressing is both breathable and stretchable which is favorable for gas exchange and adaptive to moving parts to accelerate wound healing.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.202201053