The polychloromethylation/acyloxylation of 1,6-enynes with chloroalkanes and diacyl peroxides through dual-role designs

The novel polychloromethylation/acyloxylation of 1,6-enynes with chloroalkanes and diacyl peroxides through dual-role designs has been developed to prepare 2-pyrrolidinone derivatives with polychloromethyl units with the use of an inexpensive copper salt under mild conditions. This strategy includes...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2022-09, Vol.2 (35), p.767-77
Main Authors: Zhang, Jun-Hao, Jiang, Li-Lin, Hu, Sen-Jie, Li, Jiao-Zhe, Yu, Xuan-Chi, Liu, Fa-Liang, Guan, Yu-Tao, Lei, Ke-Wei, Wei, Wen-Ting
Format: Article
Language:English
Subjects:
Organochlorine compounds
Peroxides
Substrates
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Summary:The novel polychloromethylation/acyloxylation of 1,6-enynes with chloroalkanes and diacyl peroxides through dual-role designs has been developed to prepare 2-pyrrolidinone derivatives with polychloromethyl units with the use of an inexpensive copper salt under mild conditions. This strategy includes two dual-role designs, not only improving atomic utilization but also allowing a cleaner process. The wide substrate scope and simple reaction conditions demonstrate the practicability of this protocol. The novel polychloromethylation/acyloxylation of 1,6-enynes with chloroalkanes and diacyl peroxides through dual-role designs has been developed with the use of an inexpensive copper salt under mild conditions.
ISSN:1477-0520
1477-0539
DOI:10.1039/d2ob01330d