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Determination of Perfluororganic Compounds in Whole Blood and Tissues of Laboratory Animals by Gas-Liquid Chromatography–Mass Spectrometry

A procedure for the determination of a group of perfluororganic compounds, promising for medical use, in whole blood and tissues of laboratory animals by gas-liquid chromatography–mass spectrometry was developed in in vitro experiments. The sample preparation procedure based on the liquid–liquid ext...

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Published in:	Journal of analytical chemistry (New York, N.Y.) N.Y.), 2022-09, Vol.77 (9), p.1197-1202
Main Authors:	Zhurkovich, I. K., Utsal’, V. A., Ostrovidova, E. V., Barinov, V. A., Lugovkina, N. V., Bonitenko, E. Yu, Belyakova, N. A., Barinov, V. V.
Format:	Article
Language:	English
Subjects:	Analytical Chemistry Animals Biomedical materials Blood Chemistry Chemistry and Materials Science Heptanes In vivo methods and tests Laboratory animals Liquid chromatography Liquid-liquid extraction Mass spectrometry Measurement Methods Organofluorine compounds Perfluoro compounds Perfluorodecalin Physiological aspects Spectroscopy
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container_title	Journal of analytical chemistry (New York, N.Y.)
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creator	Zhurkovich, I. K. Utsal’, V. A. Ostrovidova, E. V. Barinov, V. A. Lugovkina, N. V. Bonitenko, E. Yu Belyakova, N. A. Barinov, V. V.
description	A procedure for the determination of a group of perfluororganic compounds, promising for medical use, in whole blood and tissues of laboratory animals by gas-liquid chromatography–mass spectrometry was developed in in vitro experiments. The sample preparation procedure based on the liquid–liquid extraction of the target compounds from the biomaterial with heptane containing perfluorobenzene as an internal standard was optimized. The validation of the procedure and its testing in in vivo experiments was carried out on an example of perfluorodecalin. The time of the presence of the xenobiotic in the bloodstream and in various organs of small laboratory animals during the endotracheal route of administration was estimated.
doi_str_mv	10.1134/S1061934822070140
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subjects	Analytical Chemistry Animals Biomedical materials Blood Chemistry Chemistry and Materials Science Heptanes In vivo methods and tests Laboratory animals Liquid chromatography Liquid-liquid extraction Mass spectrometry Measurement Methods Organofluorine compounds Perfluoro compounds Perfluorodecalin Physiological aspects Spectroscopy
title	Determination of Perfluororganic Compounds in Whole Blood and Tissues of Laboratory Animals by Gas-Liquid Chromatography–Mass Spectrometry
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