Synthesis and Analgesic Activity of Methyl 2-{[(2Z)-4-Aryl-2-hydroxy-4-oxobut-2-enoyl]amino}benzoates

The reaction of methyl esters of aroylpyruvic acids with methyl 2-aminobenzoate in glacial acetic acid in the presence of anhydrous sodium acetate afforded a series of methyl 2-{[(2 Z )-4-aryl-2-hydroxy-4-oxobut-2-enoyl]amino}benzoates. The analgesic activity of the synthesized compounds was studied...

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Published in:Russian journal of general chemistry 2022-08, Vol.92 (8), p.1367-1370
Main Authors: Gein, V. L., Nazarets, O. V., Romanova, A. V., Bobrovskaya, O. V., Makhmudov, R. R.
Format: Article
Language:English
Subjects:
Acetic acid
Aromatic compounds
Benzoates
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Esters
Organic compounds
Sodium acetate
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description The reaction of methyl esters of aroylpyruvic acids with methyl 2-aminobenzoate in glacial acetic acid in the presence of anhydrous sodium acetate afforded a series of methyl 2-{[(2 Z )-4-aryl-2-hydroxy-4-oxobut-2-enoyl]amino}benzoates. The analgesic activity of the synthesized compounds was studied.
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subjects Acetic acid
Aromatic compounds
Benzoates
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Esters
Organic compounds
Sodium acetate
title Synthesis and Analgesic Activity of Methyl 2-{[(2Z)-4-Aryl-2-hydroxy-4-oxobut-2-enoyl]amino}benzoates
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