A hemilabile 2-(2′-pyridyl)-imidazole based nickel() complex: proton-coupled-electron-transfer, bactericidal and cytotoxicity studies

A 2-(2′-pyridyl)-imidazole ( L ) based water soluble nickel( ii ) complex of the type Ni L 2 Cl 2 ( 1 ) has been synthesized and characterized by spectroscopic, electrochemical, analytical and X-ray diffraction studies. Structural characterization of 1 shows a distorted octahedral environment around...

Full description

Saved in:
Bibliographic Details
Published in:New journal of chemistry 2022-09, Vol.46 (36), p.17517-17526
Main Authors: Paramanik, Krishnendu, Bandopadhyay, Nilaj, Debnath, Rakesh, Roy, Suvojit, Kotakonda, Muddukrishnaiah, Adak, Mrinal Kanti, Biswas, Bhaskar, Sankar Das, Hari
Format: Article
Language:English
Subjects:
Antibiotics
Anticancer properties
Chemical compounds
Electrochemical analysis
Hydrogen bonding
Imidazole
Ligands
Metallography
Nickel
Pharmacology
Protons
Structural analysis
Toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A 2-(2′-pyridyl)-imidazole ( L ) based water soluble nickel( ii ) complex of the type Ni L 2 Cl 2 ( 1 ) has been synthesized and characterized by spectroscopic, electrochemical, analytical and X-ray diffraction studies. Structural characterization of 1 shows a distorted octahedral environment around the nickel( ii ) center coordinated by two L ligands and two chloro ligands cis to each other. Intermolecular hydrogen-bonding, π π interactions and C-H π interactions have been investigated in detail. The irreversible electrochemical behaviour of complex 1 has been explained by considering the L -based proton-coupled-electron-transfer (PCET) mechanism. The labile nature of L and the chloro ligands in 1 is verified by substituting a biologically relevant quinonoid ligand 2,4-di- tert -butyl-6-(phenylamino)phenol, which leads to an inner-metallic chelate, 2 . Furthermore, the antibacterial activity of the complexes 1 and 2 is tested against a few clinical bacteria suggesting their significant bactericidal properties relative to a standard antibiotic, ciprofloxacin. Prominent anticancer activity of 1 and 2 against human colorectal adenocarcinoma (HT-29) cancerous cell lines is also observed with IC 50 33.5 and 45 μM, respectively, exhibiting the potential to produce promising cost-effective metallo-therapeutic agents. This study deals with the synthesis, structural characterization, proto-coupled-electron-transfer, bactericidal and cytotoxicity study of a hemilabile and water-soluble 2-(2′-pyridyl)-imidazole nickel( ii ) complex.
ISSN:1144-0546
1369-9261
DOI:10.1039/d2nj03063b