Synthesis of conjugates of 5-methyl-2-phenylpyrazol-3-ones and 1-aminoadamantanes as potential neuroprotective agents

We proposed an approach to new compounds based on conjugates of 5-methyl-2-phenylpyrazol-3-ones and 1-aminoadamantanes containing fragments of the neuroactive drugs Edaravone, Amantadine, and Memantine.

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Bibliographic Details
Published in:Russian chemical bulletin 2022-08, Vol.71 (8), p.1794-1800
Main Authors: Aksinenko, A. Yu, Goreva, T. V., Epishina, T. A., Bachurin, S. O.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Conjugates
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Inorganic Chemistry
Organic Chemistry
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Summary:We proposed an approach to new compounds based on conjugates of 5-methyl-2-phenylpyrazol-3-ones and 1-aminoadamantanes containing fragments of the neuroactive drugs Edaravone, Amantadine, and Memantine.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-022-3591-2