New polymerized sesquiterpene lactones from Ainsliaea yunnanensis and their activity evaluation

Two new dimeric and trimeric sesquiterpene lactones (1-2), and nine known sesquiterpene lactones (3-11) were isolated from the EtOAc phase of the ethanolic extract of Ainsliaea yunnanensis. Their structures were identified by NMR, IR and HR-ESIMS spectroscopic methods, and compound 1 was confirmed b...

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Bibliographic Details
Published in:Natural product research 2022-10, Vol.36 (19), p.4862-4868
Main Authors: Zhou, Na, Li, Jin-Jie, Wu, Yong, Wang, Ze-Yu, Wang, Xin, Yin, Zhi-Peng, Wang, Xin-Peng, Liu, Yi-Ran, Shang, Xiao-Ya
Format: Article
Language:English
Subjects:
activity evaluation
Ainsliaea yunnanensis
Antiinfectives and antibacterials
Cytotoxicity
Inflammasomes
Inflammation
Lactones
Microorganisms
NMR
Nuclear magnetic resonance
Sesquiterpene lactones
Single crystals
structures
X-ray diffraction
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Summary:Two new dimeric and trimeric sesquiterpene lactones (1-2), and nine known sesquiterpene lactones (3-11) were isolated from the EtOAc phase of the ethanolic extract of Ainsliaea yunnanensis. Their structures were identified by NMR, IR and HR-ESIMS spectroscopic methods, and compound 1 was confirmed by single crystal X-ray diffraction experiment. All the compounds were tested for their cytotoxic, anti-microbial and anti-inflammatory activities. Compounds 1, 2, 3, 5, 7, 9 and 11 showed very significant selective cytotoxic activities on MDA-MB-468, PANC-1, HEPG2 or A549 cells. Compounds 6 and 11 showed very significant inhibiting effect on Epicoccum sp. (CPCC 400307), Fusarium solani (CPCC 800013) or Bacillus subtilis. Meanwhile, compounds 6 and 7 can inhibit the NLRP3 inflammasome's activation at the concentration of 10 μM.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2021.1904924