Construction of a luminescent eleven-metal Zn()-Tb() nanocluster for rapid and quantitative time-gated detection of guanosine-5-monophosphate and RNA

• Published in: CrystEngComm 2022-09, Vol.24 (37), p.6527-6533
• Main Authors: Zhu, Ting, Chen, Ya, Yang, Xiaoping, Leng, Xilong, Schipper, Desmond
• Format: Article
• Language: English
• Subjects: Correlation coefficients; Delay time; Imines; Luminescence; Nanoclusters; Static models; Zinc
• ISSN: 1466-8033; 1466-8033
• DOI: 10.1039/d2ce00753c

One 11-metal Zn( ii )-Tb( iii ) nanocluster 1 was synthesized using a tetradentate Schiff base ligand. The addition of GMP and RNA results in the enhancement of Tb( iii ) luminescence of 1 , which is dominated by a static model. 1 exhibits highly sensitive TRL detection of GMP and RNA with a delay time of 300 μs, and the corresponding linear fitting equations are ( I - I 0 )/ I 0 = 10.34· C GMP − 223.42 and ( I - I 0 )/ I 0 = 6.06· C RNA − 7.47 with correlation coefficients R 2 = 0.9513 and 0.9909, respectively. The limits of detection for GMP and RNA are 3.11 μM and 0.53 ng μL −1 , respectively, and 1 can be used to determine the concentrations of GMP and RNA accurately. 1 displays a rapid and stable luminescence response to the analytes, with response times less than ten seconds and no changes for the lanthanide emission in one week. An eleven-metal Zn( ii )-Tb( iii ) nanocluster with a Schiff base ligand was constructed as a luminescent probe for quantitative time-gated detection of guanosine-5-monophosphate and RNA.