Synthesis, antibacterial and antioxidant activity of novel 12-(N-arylmethaniminyl)indolo[1,2-c]quinazolines

• Published in: Journal of Research in Pharmacy 2019-01, Vol.23 (3), p.584-595
• Main Authors: PATHAK, Devender, SHARMA, Gyanendra Kumar, DIXIT, Aditya
• Format: Article
• Language: English
• Subjects: Antioxidants
• ISSN: 2630-6344; 2630-6344
• DOI: 10.12991/jrp.2019.166

The objective of the present research was to synthesize 12-(N-arylmethaniminyl)indolo [1,2-c]quinazoline derivatives (4a1-4a11) and further characterize in terms of 1H NMR, 13C NMR, FTIR and mass spectrophotometry. Evaluation of their antibacterial and antioxidant activity was also carried out. Most compounds have shown a good antioxidant activity in all the concentrations but compounds 4a7, 4a8 and 4a11 were found to be most potent antioxidants in comparison to others with an IC50 value of 18.78 ± 1.86 μg/ml, 16.84 ± 2.60 μg/ml and 18.64 ± 2.40 μg/ml, respectively (DPPH method) and 18.83 ± 2.89 μg/ml, 16.61 ± 3.00 μg/ml & 16.8 ± 3.34 μg/ml, respectively (H2O2 method). Antibacterial activity was done against B. subtilis and E. coli with the help of agar well diffusion method and it showed that all the derivatives in the series are having good antibacterial activity but compounds 4a9 and 4a11 were found to be most promising antibacterial agents. It was concluded that the compounds containing substituted anilines (4-nitro, 4-fluoro, 4-bromo and 4-chloro-2-nitro) on the methaniminyl group of 12th position of indoloquinazoline moiety have good antioxidant and antibacterial activities.