Chemical Constituents and Bioactivities From the Leaves of Beilschmiedia Glabra Kosterm (Lauraceae)

Two butanolides, subamolide D (1) and subamolide E (2), along with β-sitosterol (3), β-sitostenone (4), lupeol (5), taraxerol (6), and 24-methylenelanosta-7,9(11)-diene-3β,15α- diol (7) were isolated from the leaves of Beilschmiedia glabra. The structures of the isolated compounds were elucidated by...

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Published in:Journal of Research in Pharmacy 2016-01, Vol.20 (3), p.401
Main Authors: Wan Mohd Nuzul Hakimi Wan Salleh, Farediah Ahmad, Khong Heng Yen, Razauden Mohamed Zulkifli
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Farediah Ahmad
Khong Heng Yen
Razauden Mohamed Zulkifli
description Two butanolides, subamolide D (1) and subamolide E (2), along with β-sitosterol (3), β-sitostenone (4), lupeol (5), taraxerol (6), and 24-methylenelanosta-7,9(11)-diene-3β,15α- diol (7) were isolated from the leaves of Beilschmiedia glabra. The structures of the isolated compounds were elucidated by extensive spectroscopic data analysis and comparison with respective literature data. The compounds were tested for DPPH• radical scavenging, antimicrobial, acetylcholinesterase and lipoxygenase inhibitory activities. Compounds 1 and 2 displayed the strongest lipoxygenase assay with an IC50 value of 5.1 and 5.5 μM, respectively. All compounds showed weak activity on DPPH• radical-scavenging, antimicrobial, and acetylcholinesterase inhibition assays.
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