The Evaluation of Salivary Thromboplastic Activity of An Acute Lymphoblastic Leukemia (ALL) Case During Treatment

• Published in: Journal of Research in Pharmacy 2014-01, Vol.18 (2), p.62
• Main Authors: CELKAN, Tiraje, YARAT, Aysen, Tugba TUNALI AKBAY, Akyüz, Serap, PISIRICILER, Rabia, YILDIZ, Inci
• Format: Article
• Language: eng ; tur
• Subjects: Leukemia
• ISSN: 2630-6344; 2630-6344
• DOI: 10.12991/mpj.2014186121

Oral cavity is a region where various mucosal lesions and infections occur. Saliva has an important role in the protection of oral cavity. Cancer and its treatment lead to several changes in oral cavity including the changes observed in saliva composition. These can affect the healing process of the oral wounds and the incidence of tooth decay. Thromboplastin (tissue factor, FIII) is a membrane bound glycoprotein and it is involved in the wound healing processes. In the present study, saliva samples were taken from an acute lymphoblastic leukemia (ALL) case at different times and were examined both biochemically and cytologically. According to the findings of this study, salivary pH differences and the increase in susceptibility to infections in the oral region may have caused the formation of mucositis and ulceration and the decrease in thromboplastic activity. We believe that early detection of infection in the oral cavity and accordingly its treatment is important in terms of patient's life quality.