A linear relationship between lamotrigine and GABA in cerebrospinal fluid

The γ-amino butyric acid (GABA)-mediated neurotransmission is useful in treating conditions like anxiety, sleep disturbances, depression and bipolar disorders. The aim of the present study is to supply evidence about neurochemical effects of acute lamotrigine treatment on GABA and L-glutamic acid le...

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Bibliographic Details
Published in:Journal of Research in Pharmacy 2011-01, Vol.1 (15), p.1-6
Main Author: Terzioglu, Berna
Format: Article
Language:English
Subjects:
Acids
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Summary:The γ-amino butyric acid (GABA)-mediated neurotransmission is useful in treating conditions like anxiety, sleep disturbances, depression and bipolar disorders. The aim of the present study is to supply evidence about neurochemical effects of acute lamotrigine treatment on GABA and L-glutamic acid levels in the cerebrospinal fluid of Wistar Albino rats and the involvement of cholinergic system. The day after the placement of concentric microdialysis probes into the lateral ventricles of rats, microdialysis experiments were performed in conscious rat model. The rats either received intraperitoneal injections of physiological saline or 20 mg/kg lamotrigine. For assessing the cholinergic involvement 0.5 mg/kg physostigmine or 2 mg/kg atropine sulfate pre-treatments were given prior to lamotrigine injection. GABA, L-glutamic acid and lamotrigine concentrations in the dialysates were analyzed using High Performance Liquid Chromatography. Saline produced no change in GABA or L-glutamic acid levels, but lamotrigine treatment significantly elevated GABA concentrations (p
ISSN:1309-0801
2630-6344
1309-0801
2630-6344
DOI:10.12991/201115437