Synthesis and anticonvulsant activity of substituted thiourea derivatives

Twelve new thiourea derivatives were prepared by the reacting of 4-aminophenylacetic acide with substituted isothiocyanates. Their chemical structures were proved by means of IR, 1H-NMR, mass spectroscopic and elemental analyses. These compounds were tested at dose of 50 mg/kg for their anticonvulsa...

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Bibliographic Details
Published in:Journal of Research in Pharmacy 2011-01, Vol.2 (15), p.43-47
Main Author: Çelen, Ahmet Özgür
Format: Article
Language:English
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Summary:Twelve new thiourea derivatives were prepared by the reacting of 4-aminophenylacetic acide with substituted isothiocyanates. Their chemical structures were proved by means of IR, 1H-NMR, mass spectroscopic and elemental analyses. These compounds were tested at dose of 50 mg/kg for their anticonvulsant activity using by pentylenetetrazole induced seizure (PTZ) and maximal electroshock seizure (MES) tests in mice. Compound 1b, (4-{[(4-chlorophenyl)thiocarbamoyl]amino}phenyl)acetic acid, was found to be more active than the other tested compounds. The compound 1b reduced convulsions in all types of grades (from grade I to V), therefore it increased convulsive threshold. It also increased onset time from 1.20 to 2.58 sec. and survival % from 50 to 95.
ISSN:1309-0801
2630-6344
1309-0801
2630-6344
DOI:10.12991/201115430