Zinc-based metal-organic frameworks: synthesis and recent progress in biomedical application

This review based on Zn-based MOF is summarized on new insights for targeted drug delivery of medicinal compounds and developed for medicinal applications. The stability of the MOF may be controlled by functionalization and the proper structure and composition choices. Thus, one of the most crucial...

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Published in:Journal of inorganic and organometallic polymers and materials 2022-09, Vol.32 (9), p.3339-3354
Main Authors: Moharramnejad, Mojtaba, Ehsani, Ali, salmani, Saba, shahi, Mehrnaz, Malekshah, Rahime Eshaghi, Robatjazi, Zahra Sadat, Parsimehr, Hamidreza
Format: Article
Language:English
Subjects:
Adsorption
Anticancer properties
Biocompatibility
Biomedical materials
Chemical compounds
Chemistry
Chemistry and Materials Science
Drug delivery systems
Functional groups
Inorganic Chemistry
Metal-organic frameworks
Organic Chemistry
Particle size distribution
Pharmacology
Polymer Sciences
Surface chemistry
Topical Reviews
Toxicity
Zinc
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Summary:This review based on Zn-based MOF is summarized on new insights for targeted drug delivery of medicinal compounds and developed for medicinal applications. The stability of the MOF may be controlled by functionalization and the proper structure and composition choices. Thus, one of the most crucial factors to consider when it comes to bio-applications of MOF is the management of their particle size distribution and the alteration of their surface. Recent research was shown that Zn-based MOF can be used as a viable delivery system for non-toxic/biocompatible medicines and therapeutic agents in biological and medical applications. The toxicity, biocompatibility, stability, and recently reported production techniques for MOF’s zinc-based building block as a possible platform with biological applications were explored and presented in this review study to offer ideal venues for further research. The factors including The surface area and pore volumes, functional groups, and synthetic methods for adsorption and desorption of drugs were studied. Antibacterial and anticancer activities of Zn-based MOF and their mechanisms were investigated. At last, the adsorption and release mechanism of drugs was investigated.
ISSN:1574-1443
1574-1451
DOI:10.1007/s10904-022-02385-y