Synthesis, Structure, and Antibacterial Activities of Diterpenoid Isosteviol-Derived Alkenyl Ethers

A series of novel isosteviol-derived alkenyl ethers were synthesized and structurally characterized by IR, NMR, and HR-MS. The tested compounds are more sensitive to Gram-positive bacteria than to Gram-negative bacteria. In particular, compound 5 exhibited better bacteriostatic activity against B. s...

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Bibliographic Details
Published in:Chemistry of natural compounds 2022-09, Vol.58 (5), p.857-861
Main Authors: Liu, Cong-Jun, Yu, Zi-Yue, Min, Yu-Tao, Zhang, Jun-Wei, Zhang, Jun, Lu, Zhen-Wei, Yang, Jiong-Peng, Wang, Yu-Fei
Format: Article
Language:English
Subjects:
Antibacterial agents
Bacteria
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Ethers
NMR
Nuclear magnetic resonance
Organic Chemistry
Plant Sciences
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Summary:A series of novel isosteviol-derived alkenyl ethers were synthesized and structurally characterized by IR, NMR, and HR-MS. The tested compounds are more sensitive to Gram-positive bacteria than to Gram-negative bacteria. In particular, compound 5 exhibited better bacteriostatic activity against B. subtilis with a minimum inhibitory concentration of 2.403 mM, whereas compounds 8 and 10 selectively inhibited the S. aureus strain.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-022-03816-5