A New Anti-Endometrial Cancer Diterpenoid Glucoside from Sheareria nana

A new diterpenoid glucoside, 15,16-dihydroxy-4-formyl-neo-clerodane-3,13 (Z)-dien-17-O-β-Dglucopyranosyl ( 1 ), was isolated from Sheareria nana S. Moore. The structure was elucidated by spectroscopic data. 1 was evaluated for cytotoxic activities against human endometrial carcinoma cells (Ishikawa...

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Bibliographic Details
Published in:Chemistry of natural compounds 2022-09, Vol.58 (5), p.870-873
Main Authors: Tang, Zhongyan, Xia, Zhengxiang
Format: Article
Language:English
Subjects:
Cancer
Care and treatment
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Chemotherapy
Endometrial cancer
Glucosides
Organic Chemistry
Plant Sciences
Toxicity
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Summary:A new diterpenoid glucoside, 15,16-dihydroxy-4-formyl-neo-clerodane-3,13 (Z)-dien-17-O-β-Dglucopyranosyl ( 1 ), was isolated from Sheareria nana S. Moore. The structure was elucidated by spectroscopic data. 1 was evaluated for cytotoxic activities against human endometrial carcinoma cells (Ishikawa and ECC-1). The results suggested that 1 exhibited moderate cytotoxic activity against Ishikawa and ECC-1 cell lines with IC50 values of 6.6 ± 0.2 and 12.1 ± 0.1 μM for 24 h respectively, whereas 1 showed no cytotoxicity against a human hepatocyte cell line. Thus, 1 was a potential choice for the treatment of endometrial carcinoma.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-022-03819-2