Enhancing the antibacterial activity of near-infrared light-triggered photothermal therapy using hybrid Au/ZnSe nanodumbbells

Photothermal therapy (PTT) for bacterial infection is an effective alternative to antibiotics. However, the excitation light with short wavelength which has unsatisfactory tissue penetration and the poor photothermal (PT) effect hinder its development. A PT agent which can achieve second near-infrar...

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Bibliographic Details
Published in:New journal of chemistry 2022-10, Vol.46 (38), p.18587-18593
Main Authors: Wang, Dong, Bi, Xinze, Ji, Lei, Fan, Yu, Wang, Hongzhi, Zhang, Jiatao
Format: Article
Language:English
Subjects:
Antibiotics
Bacteria
Bacterial infections
Conduction bands
Excitation
Gold
Heterostructures
Hot electrons
In vivo methods and tests
Light
Light irradiation
Nanorods
Near infrared radiation
Photothermal conversion
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Summary:Photothermal therapy (PTT) for bacterial infection is an effective alternative to antibiotics. However, the excitation light with short wavelength which has unsatisfactory tissue penetration and the poor photothermal (PT) effect hinder its development. A PT agent which can achieve second near-infrared (NIR-II) light induced enhanced antibacterial PTT is essential. Here, we designed and synthesized hybrid plasmonic Au/ZnSe nanodumbbell heterostructures (AZN), and applied the heterostructures to treat bacterial infection by effective PTT under NIR-II light irradiation. In the AZN heterostructures, Au nanorods (NRs) are tailored to extend the excitation light to the NIR-II regions, which provides the possibility for NIR-II light triggered PTT. The two ZnSe semiconductor caps which have a higher conduction band (CB) block hot electron injection from Au NRs. Moreover, the two ZnSe semiconductor caps, as the passivation layers, can prevent the contact of hot electrons with the surrounding medium, resulting in a higher PT conversion efficiency. Consequently, AZN produced more heat than Au NRs under the same laser irradiation. AZN exhibited outstanding antibacterial ability for both Gram-positive and Gram-negative bacteria in vitro . In vivo antibacterial tests further proved that AZN, as an excellent photothermal agent, exhibited better antibacterial ability than Au NRs. Hybrid plasmonic Au/ZnSe nanodumbbell heterostructures prevent the contact of hot electrons with the surrounding medium, resulting in higher PT conversion efficiency.
ISSN:1144-0546
1369-9261
DOI:10.1039/d2nj03142f