Regulatory effect of intracellular polysaccharides from Antrodia cinnamomea on the intestinal microbiota of mice with antibiotic-associated diarrhea

Antrodia cinnamomea is a valuable and scarce medicinal and edible mushroom. Its main active substances are triterpenoids and polysaccharides with many biological activities, such as liver protection, immunity enhancement, antitumor, anti-inflammatory, and antiviral. The long-term use of antibiotics...

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Bibliographic Details
Published in:Quality assurance and safety of crops & food 2022-01, Vol.14 (3), p.124-134
Main Authors: Lu, Chun-lei, Li, Hua-xiang, Zhu, Xiao-yan, Luo, Zhi-shan, Rao, Sheng-qi, Yang, Zhen-quan
Format: Article
Language:English
Subjects:
Antibiotics
Antrodia cinnamomea
Bacteria
Chronic illnesses
Cytokines
Diarrhea
Disorders
Drug dosages
Drug resistance
Feces
Fermentation
Flora
Fructooligosaccharides
Inflammation
Interleukin 6
Intestinal microflora
Intestine
Intracellular
Lachnospiraceae
Lincomycin
Medical research
Microbiota
Microorganisms
Phenols
Polysaccharides
Prebiotics
Proteins
Regulation
Relative abundance
Saccharides
Signs and symptoms
Software
Spleen
Sulfuric acid
Thymus gland
Triterpenoids
Tumor necrosis factor-α
Weight loss
Weight reduction
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Summary:Antrodia cinnamomea is a valuable and scarce medicinal and edible mushroom. Its main active substances are triterpenoids and polysaccharides with many biological activities, such as liver protection, immunity enhancement, antitumor, anti-inflammatory, and antiviral. The long-term use of antibiotics can easily lead to disorders in the intestinal flora and causes diarrhea, inflammation, immune decline, and other symptoms. In this study, A. cinnamomea intracellular polysaccharides (AIPSs) were extracted from mycelia in submerged fermentation, and the AIPSs with a neutral polysaccharide content of 82.74%±0.63% were obtained. Then, the therapeutic effect of AIPSs on diarrhea in mice caused by lincomycin hydrochloride (LIH), and their regulatory and recovery effects on the intestinal flora, was studied with fructooligosaccharide as the positive control. In vivo experiments in mice showed that fed intragastrically with 0.25 g/kg (bodyweight of mice) of AIPSs significantly reduced the weight loss caused by antibiotics and restored the immune-organ index (P
ISSN:1757-8361
1757-837X
DOI:10.15586/qas.v14i3.1073