Peritoneal dialysis-related peritonitis caused by gram-negative organisms: ten-years experience in a single center

Concerns are increasing about the clinical characteristics of gram- negative bacterial peritonitis for providing reference for clinical diagnosis, treatment and prevention. A retrospective analysis was performed examining patients who developed peritoneal dialysis-related peritonitis (PDRP) from 1 J...

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Bibliographic Details
Published in:Renal failure 2021-01, Vol.43 (1), p.993-1003
Main Authors: Zeng, Ying, Jiang, Linsen, Lu, Ying, Wang, Zhi, Song, Kai, Shen, Huaying, Feng, Sheng
Format: Article
Language:English
Subjects:
Adult
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
C-reactive protein
C-Reactive Protein - metabolism
Cefotaxime
Clinical Study
Drug Resistance, Microbial
E coli
Escherichia coli
Escherichia coli - drug effects
Escherichia coli - isolation & purification
Female
Gram-negative bacteria
Gram-Negative Bacteria - drug effects
Gram-Negative Bacteria - isolation & purification
gram-negative organisms
Humans
Kidney Failure, Chronic - therapy
Leukocyte Count
Logistic Models
Male
Middle Aged
Multivariate Analysis
Patients
Peritoneal dialysis
Peritoneal Dialysis - adverse effects
Peritoneum
Peritonitis
Peritonitis - drug therapy
Peritonitis - etiology
Peritonitis - microbiology
Prognosis
Retrospective Studies
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Summary:Concerns are increasing about the clinical characteristics of gram- negative bacterial peritonitis for providing reference for clinical diagnosis, treatment and prevention. A retrospective analysis was performed examining patients who developed peritoneal dialysis-related peritonitis (PDRP) from 1 January 2009 to 31 December 2018. Among 898 PD patients, 677 episodes of peritonitis occurred in 344 patients. Over 10 years, the proportion of gram-negative bacterial peritonitis increased from 0% to 26.15% (p = .045). E. coli was the leading cause (38.51%) of the 148 cases of gram-negative bacterial peritonitis. The increase of E. coli peritonitis between the first 5 and the last 5 years was obvious (20.45% vs. 46.15%). The antimicrobial sensitivity of gram-negative organisms to cefotaxime decreased from 71.43% to 55.84% (p = .017). In the gram-negative group, the effluent white cell count (WCC) on the first day was larger (OR: 1.374;95%CI: 1.248-1.563; p 
ISSN:0886-022X
1525-6049
DOI:10.1080/0886022X.2021.1939050