Acid-controlled multicomponent selective synthesis of 2,4,6-triaryl pyridines and pyrimidines by using hexamethyldisilazane as a nitrogen source under microwave irradiation

An efficient and general protocol for the synthesis of functionalized 2,4,6-triaryl pyridines and pyrimidines was developed from commercially available aromatic ketones, aldehydes and hexamethyldisilazane (HMDS) as a nitrogen source under microwave irradiation. In this multicomponent synthetic route...

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Bibliographic Details
Published in:RSC advances 2022-09, Vol.12 (42), p.27281-27291
Main Authors: Chan, Chieh-Kai, Chung, Yi-Hsiu, Wang, Cheng-Chung
Format: Article
Language:English
Subjects:
Aldehydes
Irradiation
Ketones
Lewis acid
Nitrogen
Pyridines
Pyrimidines
Synthesis
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Summary:An efficient and general protocol for the synthesis of functionalized 2,4,6-triaryl pyridines and pyrimidines was developed from commercially available aromatic ketones, aldehydes and hexamethyldisilazane (HMDS) as a nitrogen source under microwave irradiation. In this multicomponent synthetic route, Lewis acids play an important role in selectively synthesizing six-membered heterocycles, including pyridines (1N) and pyrimidines (2N), by involving [2 + 1 + 2 + 1] or [2 + 1 + 1 + 1 + 1] annulated processes. Synthesis of pyrimidines and pyridines from commercially available ketones and aldehydes by using hexamethyldisilazane as a nitrogen source and controlled by acids under microwave irradiation.
ISSN:2046-2069
2046-2069
DOI:10.1039/d2ra04739j