A Highly Water‐ and Air‐Stable Iron‐Containing MRI Contrast Agent Sensor for H2O2

A highly water‐ and air‐stable Fe(II) complex with the quinol‐containing macrocyclic ligand H4qp4 reacts with H2O2 to yield Fe(III) complexes with less highly chelating forms of the ligand that have either one or two para‐quinones. The reaction increases the T1‐weighted relaxivity over four‐fold, en...

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Bibliographic Details
Published in:Chemistry : a European journal 2022-08, Vol.28 (46), p.n/a
Main Authors: Karbalaei, Sana, Franke, Alicja, Jordan, Aubree, Rose, Cayla, Pokkuluri, P. Raj, Beyers, Ronald J., Zahl, Achim, Ivanović‐Burmazović, Ivana, Goldsmith, Christian R.
Format: Article
Language:English
Subjects:
Chelation
Chemistry
Contrast agents
Hydrogen peroxide
Iron
Ligands
Magnetic resonance imaging
Manganese
Oxidation
Quinones
reactive oxygen species
redox
sensors
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Summary:A highly water‐ and air‐stable Fe(II) complex with the quinol‐containing macrocyclic ligand H4qp4 reacts with H2O2 to yield Fe(III) complexes with less highly chelating forms of the ligand that have either one or two para‐quinones. The reaction increases the T1‐weighted relaxivity over four‐fold, enabling the complex to detect H2O2 using clinical MRI technology. The iron‐containing sensor differs from its recently characterized manganese analog, which also detects H2O2, in that it is the oxidation of the metal center, rather than the ligand, that primarily enhances the relaxivity. An Fe(II) complex with the macrocyclic quinol‐containing ligand H4qp4 displays high water‐ and air‐stability. The complex rapidly reacts with H2O2, but not O2, to yield Fe(III) complexes with oxidized ligands that contain para‐quinone groups. Upon oxidation by H2O2, the r1 increases by over four‐fold, enabling the Fe(II) complex to act as an MRI contrast agent sensor for this reactive oxygen species.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.202201179