Loading…

Rapid Hydrolysis and Derivatization of Nitrofuran Metabolites with a New Derivatizing Agent 5-Nitro-2-Furaldehyde in Their Determination in Chicken Meat by HPLC–MS/MS

We proposed a procedure for the rapid sample preparation of food samples for the determination of nitrofuran metabolites in them by HPLC–MS/MS, using 5-nitro-2-furaldehyde as a new derivatizing agent. Meat samples from broiler chickens treated with nitrofurans for 10 days were used to demonstrate th...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of analytical chemistry (New York, N.Y.) N.Y.), 2022-10, Vol.77 (10), p.1300-1306
Main Authors:	Melekhin, A. O., Tolmacheva, V. V., Kholyavskaya, Yu. N., Sedykh, E. S., Dmitrienko, S. G., Apyari, V. V., Bairov, A. L.
Format:	Article
Language:	English
Subjects:	Analysis Analytical Chemistry Chemistry Chemistry and Materials Science Chickens Furans High performance liquid chromatography Hydrochloric acid Hydrolysis Mass spectrometry Meat Metabolites Methods Nitrogen compounds
Citations:	Items that this one cites Items that cite this one
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

cited_by	cdi_FETCH-LOGICAL-c385t-8bbe63ec41fb17147bc0b9ab65c46da8b4c52a1666b6f1b322c9745e5ea4366b3
cites	cdi_FETCH-LOGICAL-c385t-8bbe63ec41fb17147bc0b9ab65c46da8b4c52a1666b6f1b322c9745e5ea4366b3
container_end_page	1306
container_issue	10
container_start_page	1300
container_title	Journal of analytical chemistry (New York, N.Y.)
container_volume	77
creator	Melekhin, A. O. Tolmacheva, V. V. Kholyavskaya, Yu. N. Sedykh, E. S. Dmitrienko, S. G. Apyari, V. V. Bairov, A. L.
description	We proposed a procedure for the rapid sample preparation of food samples for the determination of nitrofuran metabolites in them by HPLC–MS/MS, using 5-nitro-2-furaldehyde as a new derivatizing agent. Meat samples from broiler chickens treated with nitrofurans for 10 days were used to demonstrate that the time of hydrolysis–derivatization in a thermostated ultrasonic bath could be significantly shortened by raising temperature to 80°C and increasing the concentration of hydrochloric acid to 0.5 M. Metabolites of Furaltadone, Furazolidone, Nitrofurantoin, and Nitrofurazone in chicken meat, liver, stomach, and heart are determined using the developed procedure and an official method. The proposed method ensures the quantitative isolation of metabolites.
doi_str_mv	10.1134/S1061934822100112
format	article
fullrecord	<record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_2722728497</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A721542325</galeid><sourcerecordid>A721542325</sourcerecordid><originalsourceid>FETCH-LOGICAL-c385t-8bbe63ec41fb17147bc0b9ab65c46da8b4c52a1666b6f1b322c9745e5ea4366b3</originalsourceid><addsrcrecordid>eNp1ks2O0zAQgCMEEsvCA3CzxIlDdv0XJzlWhaUrtQvaLufIdiapl9QutssSTrwDL8Fz8SS4FKmqKLItWzPf55FGk2UvCb4ghPHLJcGC1IxXlBKMCaGPsjMicJUzUteP0zul813-afYshHuMcV0RcZb9vJUb06LZ2Ho3jMEEJG2L3oA3X2Q039JxFrkO3ZjoXbf10qIFRKncYCIE9GDiCkl0Aw8Hx9geTXqwERX5Hy2n-VUyhxZWYwvIWHS3AuOTEcGvjd0XSeHpyuhPsKsgI1Ijmn2YT399_7FYXi6Wz7MnnRwCvPh7n2cfr97eTWf5_P276-lknmtWFTGvlALBQHPSKVISXiqNVS2VKDQXrawU1wWVRAihREcUo1TXJS-gAMlZCrLz7NX-3413n7cQYnPvtt6mkg0tadoVr8sD1csBGmM7F73UaxN0MykpKThltEhUfoJKrYHUDWehMyl8xF-c4NNqYW30SeH1kZCYCF9jL7chNNfL22OW7FntXQgeumbjzVr6sSG42c1Q888MJYfunZBY24M_NOP_0m-3isdJ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2722728497</pqid></control><display><type>article</type><title>Rapid Hydrolysis and Derivatization of Nitrofuran Metabolites with a New Derivatizing Agent 5-Nitro-2-Furaldehyde in Their Determination in Chicken Meat by HPLC–MS/MS</title><source>Springer Link</source><creator>Melekhin, A. O. ; Tolmacheva, V. V. ; Kholyavskaya, Yu. N. ; Sedykh, E. S. ; Dmitrienko, S. G. ; Apyari, V. V. ; Bairov, A. L.</creator><creatorcontrib>Melekhin, A. O. ; Tolmacheva, V. V. ; Kholyavskaya, Yu. N. ; Sedykh, E. S. ; Dmitrienko, S. G. ; Apyari, V. V. ; Bairov, A. L.</creatorcontrib><description>We proposed a procedure for the rapid sample preparation of food samples for the determination of nitrofuran metabolites in them by HPLC–MS/MS, using 5-nitro-2-furaldehyde as a new derivatizing agent. Meat samples from broiler chickens treated with nitrofurans for 10 days were used to demonstrate that the time of hydrolysis–derivatization in a thermostated ultrasonic bath could be significantly shortened by raising temperature to 80°C and increasing the concentration of hydrochloric acid to 0.5 M. Metabolites of Furaltadone, Furazolidone, Nitrofurantoin, and Nitrofurazone in chicken meat, liver, stomach, and heart are determined using the developed procedure and an official method. The proposed method ensures the quantitative isolation of metabolites.</description><identifier>ISSN: 1061-9348</identifier><identifier>EISSN: 1608-3199</identifier><identifier>DOI: 10.1134/S1061934822100112</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Analysis ; Analytical Chemistry ; Chemistry ; Chemistry and Materials Science ; Chickens ; Furans ; High performance liquid chromatography ; Hydrochloric acid ; Hydrolysis ; Mass spectrometry ; Meat ; Metabolites ; Methods ; Nitrogen compounds</subject><ispartof>Journal of analytical chemistry (New York, N.Y.), 2022-10, Vol.77 (10), p.1300-1306</ispartof><rights>Pleiades Publishing, Ltd. 2022. ISSN 1061-9348, Journal of Analytical Chemistry, 2022, Vol. 77, No. 10, pp. 1300–1306. © Pleiades Publishing, Ltd., 2022. Russian Text © The Author(s), 2022, published in Zhurnal Analiticheskoi Khimii, 2022, Vol. 77, No. 10, pp. 938–946.</rights><rights>COPYRIGHT 2022 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-8bbe63ec41fb17147bc0b9ab65c46da8b4c52a1666b6f1b322c9745e5ea4366b3</citedby><cites>FETCH-LOGICAL-c385t-8bbe63ec41fb17147bc0b9ab65c46da8b4c52a1666b6f1b322c9745e5ea4366b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Melekhin, A. O.</creatorcontrib><creatorcontrib>Tolmacheva, V. V.</creatorcontrib><creatorcontrib>Kholyavskaya, Yu. N.</creatorcontrib><creatorcontrib>Sedykh, E. S.</creatorcontrib><creatorcontrib>Dmitrienko, S. G.</creatorcontrib><creatorcontrib>Apyari, V. V.</creatorcontrib><creatorcontrib>Bairov, A. L.</creatorcontrib><title>Rapid Hydrolysis and Derivatization of Nitrofuran Metabolites with a New Derivatizing Agent 5-Nitro-2-Furaldehyde in Their Determination in Chicken Meat by HPLC–MS/MS</title><title>Journal of analytical chemistry (New York, N.Y.)</title><addtitle>J Anal Chem</addtitle><description>We proposed a procedure for the rapid sample preparation of food samples for the determination of nitrofuran metabolites in them by HPLC–MS/MS, using 5-nitro-2-furaldehyde as a new derivatizing agent. Meat samples from broiler chickens treated with nitrofurans for 10 days were used to demonstrate that the time of hydrolysis–derivatization in a thermostated ultrasonic bath could be significantly shortened by raising temperature to 80°C and increasing the concentration of hydrochloric acid to 0.5 M. Metabolites of Furaltadone, Furazolidone, Nitrofurantoin, and Nitrofurazone in chicken meat, liver, stomach, and heart are determined using the developed procedure and an official method. The proposed method ensures the quantitative isolation of metabolites.</description><subject>Analysis</subject><subject>Analytical Chemistry</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chickens</subject><subject>Furans</subject><subject>High performance liquid chromatography</subject><subject>Hydrochloric acid</subject><subject>Hydrolysis</subject><subject>Mass spectrometry</subject><subject>Meat</subject><subject>Metabolites</subject><subject>Methods</subject><subject>Nitrogen compounds</subject><issn>1061-9348</issn><issn>1608-3199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1ks2O0zAQgCMEEsvCA3CzxIlDdv0XJzlWhaUrtQvaLufIdiapl9QutssSTrwDL8Fz8SS4FKmqKLItWzPf55FGk2UvCb4ghPHLJcGC1IxXlBKMCaGPsjMicJUzUteP0zul813-afYshHuMcV0RcZb9vJUb06LZ2Ho3jMEEJG2L3oA3X2Q039JxFrkO3ZjoXbf10qIFRKncYCIE9GDiCkl0Aw8Hx9geTXqwERX5Hy2n-VUyhxZWYwvIWHS3AuOTEcGvjd0XSeHpyuhPsKsgI1Ijmn2YT399_7FYXi6Wz7MnnRwCvPh7n2cfr97eTWf5_P276-lknmtWFTGvlALBQHPSKVISXiqNVS2VKDQXrawU1wWVRAihREcUo1TXJS-gAMlZCrLz7NX-3413n7cQYnPvtt6mkg0tadoVr8sD1csBGmM7F73UaxN0MykpKThltEhUfoJKrYHUDWehMyl8xF-c4NNqYW30SeH1kZCYCF9jL7chNNfL22OW7FntXQgeumbjzVr6sSG42c1Q888MJYfunZBY24M_NOP_0m-3isdJ</recordid><startdate>20221001</startdate><enddate>20221001</enddate><creator>Melekhin, A. O.</creator><creator>Tolmacheva, V. V.</creator><creator>Kholyavskaya, Yu. N.</creator><creator>Sedykh, E. S.</creator><creator>Dmitrienko, S. G.</creator><creator>Apyari, V. V.</creator><creator>Bairov, A. L.</creator><general>Pleiades Publishing</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope></search><sort><creationdate>20221001</creationdate><title>Rapid Hydrolysis and Derivatization of Nitrofuran Metabolites with a New Derivatizing Agent 5-Nitro-2-Furaldehyde in Their Determination in Chicken Meat by HPLC–MS/MS</title><author>Melekhin, A. O. ; Tolmacheva, V. V. ; Kholyavskaya, Yu. N. ; Sedykh, E. S. ; Dmitrienko, S. G. ; Apyari, V. V. ; Bairov, A. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-8bbe63ec41fb17147bc0b9ab65c46da8b4c52a1666b6f1b322c9745e5ea4366b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Analysis</topic><topic>Analytical Chemistry</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chickens</topic><topic>Furans</topic><topic>High performance liquid chromatography</topic><topic>Hydrochloric acid</topic><topic>Hydrolysis</topic><topic>Mass spectrometry</topic><topic>Meat</topic><topic>Metabolites</topic><topic>Methods</topic><topic>Nitrogen compounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Melekhin, A. O.</creatorcontrib><creatorcontrib>Tolmacheva, V. V.</creatorcontrib><creatorcontrib>Kholyavskaya, Yu. N.</creatorcontrib><creatorcontrib>Sedykh, E. S.</creatorcontrib><creatorcontrib>Dmitrienko, S. G.</creatorcontrib><creatorcontrib>Apyari, V. V.</creatorcontrib><creatorcontrib>Bairov, A. L.</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Science</collection><jtitle>Journal of analytical chemistry (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Melekhin, A. O.</au><au>Tolmacheva, V. V.</au><au>Kholyavskaya, Yu. N.</au><au>Sedykh, E. S.</au><au>Dmitrienko, S. G.</au><au>Apyari, V. V.</au><au>Bairov, A. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rapid Hydrolysis and Derivatization of Nitrofuran Metabolites with a New Derivatizing Agent 5-Nitro-2-Furaldehyde in Their Determination in Chicken Meat by HPLC–MS/MS</atitle><jtitle>Journal of analytical chemistry (New York, N.Y.)</jtitle><stitle>J Anal Chem</stitle><date>2022-10-01</date><risdate>2022</risdate><volume>77</volume><issue>10</issue><spage>1300</spage><epage>1306</epage><pages>1300-1306</pages><issn>1061-9348</issn><eissn>1608-3199</eissn><abstract>We proposed a procedure for the rapid sample preparation of food samples for the determination of nitrofuran metabolites in them by HPLC–MS/MS, using 5-nitro-2-furaldehyde as a new derivatizing agent. Meat samples from broiler chickens treated with nitrofurans for 10 days were used to demonstrate that the time of hydrolysis–derivatization in a thermostated ultrasonic bath could be significantly shortened by raising temperature to 80°C and increasing the concentration of hydrochloric acid to 0.5 M. Metabolites of Furaltadone, Furazolidone, Nitrofurantoin, and Nitrofurazone in chicken meat, liver, stomach, and heart are determined using the developed procedure and an official method. The proposed method ensures the quantitative isolation of metabolites.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S1061934822100112</doi><tpages>7</tpages></addata></record>
fulltext	fulltext
identifier	ISSN: 1061-9348
ispartof	Journal of analytical chemistry (New York, N.Y.), 2022-10, Vol.77 (10), p.1300-1306
issn	1061-9348 1608-3199
language	eng
recordid	cdi_proquest_journals_2722728497
source	Springer Link
subjects	Analysis Analytical Chemistry Chemistry Chemistry and Materials Science Chickens Furans High performance liquid chromatography Hydrochloric acid Hydrolysis Mass spectrometry Meat Metabolites Methods Nitrogen compounds
title	Rapid Hydrolysis and Derivatization of Nitrofuran Metabolites with a New Derivatizing Agent 5-Nitro-2-Furaldehyde in Their Determination in Chicken Meat by HPLC–MS/MS
url	http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T11%3A02%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Rapid%20Hydrolysis%20and%20Derivatization%20of%20Nitrofuran%20Metabolites%20with%20a%20New%20Derivatizing%20Agent%205-Nitro-2-Furaldehyde%20in%20Their%20Determination%20in%20Chicken%20Meat%20by%20HPLC%E2%80%93MS/MS&rft.jtitle=Journal%20of%20analytical%20chemistry%20(New%20York,%20N.Y.)&rft.au=Melekhin,%20A.%20O.&rft.date=2022-10-01&rft.volume=77&rft.issue=10&rft.spage=1300&rft.epage=1306&rft.pages=1300-1306&rft.issn=1061-9348&rft.eissn=1608-3199&rft_id=info:doi/10.1134/S1061934822100112&rft_dat=%3Cgale_proqu%3EA721542325%3C/gale_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c385t-8bbe63ec41fb17147bc0b9ab65c46da8b4c52a1666b6f1b322c9745e5ea4366b3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2722728497&rft_id=info:pmid/&rft_galeid=A721542325&rfr_iscdi=true