Multicentre, randomised study found that honey had no pharmacological effect on nocturnal coughs and sleep quality at 1–5years of age

• Published in: Acta Paediatrica 2022-11, Vol.111 (11), p.2157-2164
• Main Authors: Nishimura, Tatsuo, Muta, Hiromi, Hosaka, Taisuke, Ueda, Makoto, Kishida, Kazue
• Format: Article
• Language: English
• Subjects: Cough; Honey; Patients; Placebos; Respiratory tract diseases; Sleep; Syrups
• ISSN: 0803-5253; 1651-2227
• DOI: 10.1111/apa.16509

AimThe World Health Organization has listed honey as a potential treatment for coughs, but there is little evidence to support its use for coughs associated with upper respiratory tract infections (URTIs). This study evaluated how effective honey was for treating nocturnal coughs and sleep difficulties.MethodsThis multicentre, randomised, double‐blind, placebo‐controlled study focused on patients aged 1–5 years with URTIs and coughs for up to 7 days. They were recruited from 13 general paediatric community clinics in Japan. The participants were given acacia honey or a honey‐flavoured syrup placebo in the hour before they were put down to sleep on 2 consecutive nights. Their nocturnal cough and sleep difficulties were assessed on both nights using a 7‐point Likert scale.ResultsThe data collection for 161 patients took place between 20 November 2021 and 28 February 2022, with 78 randomly allocated to the honey group and 83 to the syrup placebo group. Both groups showed improvements on both the first and second nights, with no significant differences between the two groups.ConclusionBoth groups showed improvements in their nocturnal coughs and sleep difficulties during the 2‐night study, but honey was no more effective than the syrup placebo.