Enantioselective Nickel‐Catalyzed C(sp3)−H Activation of Formamides

Enantioselective Ni‐catalyzed C(sp3)−H bond activation remains an elusive challenge. Herein, we used phosphine oxide‐ligated Ni−Al bimetallic catalyst to realize enantioselective Ni‐catalyzed aliphatic C(sp3)−H activation of formamides, providing a series of chiral N‐containing heterocycles in 40–95...

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Bibliographic Details
Published in:Angewandte Chemie 2022-10, Vol.134 (42), p.n/a
Main Authors: Wang, Yin‐Xia, Zhang, Feng‐Ping, Chen, Hao, Li, Yue, Li, Jiang‐Fei, Ye, Mengchun
Format: Article
Language:English
Subjects:
Bimetal
Bimetals
Catalysts
Chemistry
Cyclization
C−H Functionalization
Enantiomers
Formamides
Hydrogen bonds
Nickel
Phosphine
Phosphine oxide
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Summary:Enantioselective Ni‐catalyzed C(sp3)−H bond activation remains an elusive challenge. Herein, we used phosphine oxide‐ligated Ni−Al bimetallic catalyst to realize enantioselective Ni‐catalyzed aliphatic C(sp3)−H activation of formamides, providing a series of chiral N‐containing heterocycles in 40–95 % yield and 70–95 % ee. Enantioselective Ni‐catalyzed C(sp3)−H activation via C−H nickellation remains an elusive challenge. Herein, we used phosphine oxide (H8‐BINAPO) ligated Ni‐Al bimetallic catalyst to achieve an enantioselective Ni‐catalyzed aliphatic C(sp3)−H activation with up to 95 % yield and up 95 % ee for the first time.
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.202209625