Transition Metal‐Catalyzed Reactions and Solid‐Phase Synthesis: A Convenient Blend

• Published in: European journal of organic chemistry 2022-10, Vol.2022 (38), p.n/a
• Main Authors: Cornier, Patricia G., Delpiccolo, Carina M. L., Martiren, Nadia L., Mata, Ernesto G., Mendez, Luciana, Squizatto, Caterina Permingeat, Pizzio, Marianela G.
• Format: Article
• Language: English
• Subjects: Chemical reactions; CuAAC reactions; Metathesis; Organic chemistry; Palladium; Pd-catalyzed couplings; Phase transitions; Ru-mediated metathesis; Solid phase synthesis; Transition metals; Transition-metal catalysis
• ISSN: 1434-193X; 1099-0690
• DOI: 10.1002/ejoc.202200526

Transition metal‐catalyzed, C−C and C−N bond‐forming reactions have made an enormous impact in the way complex molecules are assembled. The benefits of solid‐phase chemistry soon made this type of reaction applicable to solid‐supported processes. In this review, we report the most recent applications and possibilities of this combination. Remarkably, the solid‐phase CuAAC and ring‐closing metathesis have demonstrated an important role in synthetic biology, alike more traditional Pd‐catalyzed reactions, such as Suzuki‐Miyaura, Heck, Sonogashira, which are valuable tools for accessing libraries of biologically relevant small molecules. Examples proved the validity of solid‐phase transition metal‐catalyzed reactions as a practical and fast strategy to cover the current organic chemistry demands. The most recent applications and possibilities of transition metal‐catalyzed reactions on solid phase are reviewed, which is a practical and fast strategy to cover current organic chemistry demands. Remarkably, solid‐phase CuAAC and ring‐closing metathesis have demonstrated an important role in synthetic biology, while more traditional Pd‐catalyzed reactions, like Suzuki‐Miyaura, Heck, and Sonogashira reactions, are valuable tools for accessing libraries of bioactive compounds.