Fluorodeoxyglucose-Positron Emission Tomography–Computed Tomography Features of Atypical Femoral Lesions in Patients Prescribed Bone-modifying Agents: Two Case Reports

Careful multiplanar reformation (MPR) scrutiny of CT images on FDG-PET-CT might reveal the beaking typical of a pre-AFF lesion in the proximal femur, and thus offer a chance for timely plain radiograph confirmation and consideration of prophylactic fixation based on full assessment of clinical and i...

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Bibliographic Details
Published in:Hong Kong journal of radiology : HKJR = Xianggang fang she ke yi xue za zhi 2022-07, Vol.25 (2), p.e8-e11
Main Authors: Kumamoto, W, Cheng, LY, Shen, WY
Format: Article
Language:English
Subjects:
Biopsy
Bisphosphonates
Breast cancer
Cancer therapies
Case reports
Chemotherapy
Drug dosages
Drug withdrawal
Fractures
Histopathology
Mastectomy
Metastasis
Monoclonal antibodies
Patients
Tomography
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Summary:Careful multiplanar reformation (MPR) scrutiny of CT images on FDG-PET-CT might reveal the beaking typical of a pre-AFF lesion in the proximal femur, and thus offer a chance for timely plain radiograph confirmation and consideration of prophylactic fixation based on full assessment of clinical and imaging findings. Magnified co-registered positron emissiontomography[-]computed tomography images in (a) axial, (b) coronal,and (c) sagittal views showing non-fluorodeoxyglucose-avidity atthe corresponding site Case 2 In October 2018, a 61-year-old woman presented with right hip pain. 6 years before this, the patient was diagnosed with carcinoma of the breast, which was treated with mastectomy and chemotherapy. 1 year later, the patient was started on high-dose denosumab (120 mg every 4 weeks), continuing to the present ([greater than]5 y of denosumab therapy). Because PET-CT is regularly used to monitor disease progress in patients prescribed BMAs/BTAs, radiologists should be specifically alerted to their drug history.
ISSN:2223-6619
2307-4620
DOI:10.12809/hkjr2217336