Neurotoxicity mechanism of Ochratoxin A

Mycotoxins, such as Ochratoxins, are widely distributed in nature and are common contaminants of human foodstuffs. Ochratoxins are a group of mycotoxins produced by a wide range of molds. Ochratoxin A (OTA), the most prominent member of this toxin family, is produced by various Aspergillus and Penic...

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Bibliographic Details
Published in:Quality assurance and safety of crops & food 2021-04, Vol.13 (2), p.34-45
Main Authors: Nourbakhsh, Fahimeh, Tajbakhsh, Elahe
Format: Article
Language:English
Subjects:
Apoptosis
Barley
Cancer
Carcinogens
Cereals
Coffee
Contaminants
DNA damage
Food contamination
Food contamination & poisoning
Fungi
Genotoxicity
Inflammation
Kinases
Lipids
Meat products
Medical research
Metabolism
Metabolites
Mycotoxins
Neurotoxicity
Neurotoxins
Ochratoxin A
Plasma
Proteins
Seeds
Teratogenicity
Toxicity
Toxins
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Summary:Mycotoxins, such as Ochratoxins, are widely distributed in nature and are common contaminants of human foodstuffs. Ochratoxins are a group of mycotoxins produced by a wide range of molds. Ochratoxin A (OTA), the most prominent member of this toxin family, is produced by various Aspergillus and Penicillium species. OTA is frequently found in foods such as cereals, oleaginous seeds, coffee, and meat products. This mycotoxin has been described as teratogenic, genotoxic, carcinogenic, and immunotoxic, and has been proven to be a potent neurotoxin. In the present study, the neurotoxicological perspective of OTA was reviewed and discussed. The main possible mechanisms of neurotoxicity are oxidative DNA, protein and lipid damage, and apoptosis. However, further studies are needed to conclude the exact neurotoxicity mechanism of OTA and find the approaches that reduce the neurotoxicity induced by OTA.
ISSN:1757-8361
1757-837X
DOI:10.15586/qas.v13i2.837