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Neurotoxicity mechanism of Ochratoxin A
Mycotoxins, such as Ochratoxins, are widely distributed in nature and are common contaminants of human foodstuffs. Ochratoxins are a group of mycotoxins produced by a wide range of molds. Ochratoxin A (OTA), the most prominent member of this toxin family, is produced by various Aspergillus and Penic...
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| Published in: | Quality assurance and safety of crops & food 2021-04, Vol.13 (2), p.34-45 |
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| container_title | Quality assurance and safety of crops & food |
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| creator | Nourbakhsh, Fahimeh Tajbakhsh, Elahe |
| description | Mycotoxins, such as Ochratoxins, are widely distributed in nature and are common contaminants of human foodstuffs. Ochratoxins are a group of mycotoxins produced by a wide range of molds. Ochratoxin A (OTA), the most prominent member of this toxin family, is produced by various Aspergillus and Penicillium species. OTA is frequently found in foods such as cereals, oleaginous seeds, coffee, and meat products. This mycotoxin has been described as teratogenic, genotoxic, carcinogenic, and immunotoxic, and has been proven to be a potent neurotoxin. In the present study, the neurotoxicological perspective of OTA was reviewed and discussed. The main possible mechanisms of neurotoxicity are oxidative DNA, protein and lipid damage, and apoptosis. However, further studies are needed to conclude the exact neurotoxicity mechanism of OTA and find the approaches that reduce the neurotoxicity induced by OTA. |
| doi_str_mv | 10.15586/qas.v13i2.837 |
| format | article |
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| ispartof | Quality assurance and safety of crops & food, 2021-04, Vol.13 (2), p.34-45 |
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| language | eng |
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| subjects | Apoptosis Barley Cancer Carcinogens Cereals Coffee Contaminants DNA damage Food contamination Food contamination & poisoning Fungi Genotoxicity Inflammation Kinases Lipids Meat products Medical research Metabolism Metabolites Mycotoxins Neurotoxicity Neurotoxins Ochratoxin A Plasma Proteins Seeds Teratogenicity Toxicity Toxins |
| title | Neurotoxicity mechanism of Ochratoxin A |
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