Metal‐Free One‐Pot Synthesis of Tri‐ and Difluoromethylated Bis(carbazolyl)methanes

A general, efficient and regioselective protocol has been developed for the synthesis of trifluoromethylated bis(carbazolyl)methanes. This metal‐free transformation proceeds smoothly under air atmosphere and features broad scope for both reaction partners. This method could also be extended to the s...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2022-10, Vol.364 (20), p.3477-3482
Main Authors: Ma, Feng, Wu, Xian‐Tao, Miao, Le‐Wei, Sun, Fuxing, Jiang, Yi‐Jun, Chen, Peng
Format: Article
Language:English
Subjects:
Alkylation
Bis(carbazolyl)methanes
Fluoromethylated compounds
Friedel-Crafts reaction
One-pot synthesis
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Summary:A general, efficient and regioselective protocol has been developed for the synthesis of trifluoromethylated bis(carbazolyl)methanes. This metal‐free transformation proceeds smoothly under air atmosphere and features broad scope for both reaction partners. This method could also be extended to the synthesis of difluoromethylated and chlorodifluoromethylated bis(carbazolyl)methanes.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202200459