Synthesis, characterization of silver nanoparticles from Punica granatum L. and its in vitro antidiabetic activity

Ecofriendly nanoparticle synthesis is an ongoing worldwide effort to treat many human diseases. In the present study, Punica granatum peel extract is a reducing agent for green synthesizing silver nanoparticles (AgNPs). Further partially characterized by preliminary phytochemical screening, UV–visib...

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Bibliographic Details
Published in:Nanotechnology for environmental engineering 2022-12, Vol.7 (4), p.923-930
Main Authors: Saminathan, Usharani, Ramasamy, Pasiyappazham, Chinathambi, Anjalidevi, Paramasivam, Sivagurunathan, Vadamalai, Sumathi, Chinnaiyan, Uma, Singh, Rajesh
Format: Article
Language:English
Subjects:
Amylases
Antimicrobial agents
Cancer
Carbohydrates
Chromatography
Diabetes
Diabetes mellitus
Earth and Environmental Science
Earth Sciences
Environment
Environmental engineering
Environmental Science and Engineering
Enzymatic activity
Enzyme activity
Enzymes
Fourier transforms
Fruits
Gas chromatography
Glucosidase
Infrared analysis
Infrared spectroscopy
Mass spectroscopy
Medicine
Nanoparticles
Nanotechnology
Nanotechnology and Microengineering
Original Paper
Pharmaceutical industry
Phytochemicals
Plant extracts
Potassium
Punica granatum
Reducing agents
Scientific imaging
Silver
Solvents
Spectroscopic analysis
Synthesis
α-Amylase
α-Glucosidase
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Summary:Ecofriendly nanoparticle synthesis is an ongoing worldwide effort to treat many human diseases. In the present study, Punica granatum peel extract is a reducing agent for green synthesizing silver nanoparticles (AgNPs). Further partially characterized by preliminary phytochemical screening, UV–visible spectroscopy analysis, Fourier-transform infrared spectroscopy (FT-IR) and gas chromatography–mass spectroscopy analysis (GC–MS). AgNPs potential was confirmed by in vitro antidiabetic activity, and its ability to inhibit carbohydrate digesting enzymes. AgNPs showed the least inhibition of enzymes with the highest value of 84.0% at 20 mg / ml, 79.0% at 20 mg / ml concentration of α-amylase and α-glucosidase enzyme activity, respectively. The enzymatic assay results revealed the existence of AgNPs can exhibit the dose-dependent inhibition on α Amylase enzyme α-glucosidase potentials. Our results suggest that P. granatum peel extract contains (AgNPs) a good antidiabetic agent against the key enzymes involved in diabetes. Hence, moral activity can be used to make appropriate nanomedicines and pharmaceutical industries.
ISSN:2365-6379
2365-6387
DOI:10.1007/s41204-022-00278-6