Interleukin-33 is up-regulated in serum of asthma patients

This study sought to determine the significance of IL-33 in.pathogenesis of asthma in adult patients. Interleukin-33 (IL-33) is suggested to influence asthma pathogenesis. A case-control study was conducted on 104 asthma patients and 111 healthy subjects. Enzyme-linked immunosorbent assay was used t...

Full description

Saved in:
Bibliographic Details
Main Authors: Shaban, Semaa A., Brakhas, Suad A., Ad’hiah, Ali H.
Format: Conference Proceeding
Language:English
Subjects:
Asthma
Interleukins
Pathogenesis
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study sought to determine the significance of IL-33 in.pathogenesis of asthma in adult patients. Interleukin-33 (IL-33) is suggested to influence asthma pathogenesis. A case-control study was conducted on 104 asthma patients and 111 healthy subjects. Enzyme-linked immunosorbent assay was used to determine the IL-33 level. The median level of IL-33 was significantly elevated in asthma patients compared to controls (74.2 vs. 64.3 pg/ml; p < 0.001). Patients grouped by family history, disease severity and atopy showed no significant differences between IL-33 levels. Receiver operating characteristic curve analysis of IL-33 estimated an area under curve of 0.641 (95% CI: 0.565 - 0.716; p < 0.001). At a cut-off value of 68.3 pg/ml, the diagnostic sensitivity and specificity of IL-33 were 60.6 and 59.5%, respectively. This study indicated that IL-33 was up-regulated in serum of asthma patients, and therefore, its role in pathogenesis of disease is suggested.
ISSN:0094-243X
1551-7616
DOI:10.1063/5.0093366