Role of anti-Mullerian hormone in polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is the most common gynecological endocrine disorders affecting up to 10% of all females in their reproductive age, and its cause of onset is still elusive. A spectrum of recent research reflected diverse associations between increased plasma level of anti-Mullerian h...

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Bibliographic Details
Published in:Middle East Fertility Society Journal 2022-12, Vol.27 (1), p.1-10
Main Authors: Bhattacharya, Koushik, Saha, Ishita, Sen, Debanjana, Bose, Chaitali, Chaudhuri, Gargi Ray, Dutta, Sulagna, Sengupta, Pallav
Format: Article
Language:English
Subjects:
Age
Androgens
Anti-Mullerian hormone
Estrogens
Females
Folliculogenesis
Gonadotropins
Growth factors
Hormones
Insulin resistance
Ovarian reserve
Ovaries
Pathophysiology
Physiology
Polycystic ovary syndrome
Proteins
Reproductive system
Stein-Leventhal syndrome
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Summary:Polycystic ovary syndrome (PCOS) is the most common gynecological endocrine disorders affecting up to 10% of all females in their reproductive age, and its cause of onset is still elusive. A spectrum of recent research reflected diverse associations between increased plasma level of anti-Mullerian hormone (AMH) and different clinical features of PCOS. Since AMH levels reflect the pool of growing follicles that potentially can ovulate, it can be stated that serum AMH levels can be used to assess the "functional ovarian reserve," rather mentioning it as the "ovarian reserve." AMH also appears to be a premier endocrine parameter for the assessment of atrophied ovarian follicular pool in response to age of individuals. AMH hinders the follicular development as well as the follicular recruitment and ultimately resulting in follicular arrest which is the key pathophysiologic condition for the onset of PCOS. Furthermore, FSH-induced aromatase activity remains inhibited by AMH that aids emergence of other associated clinical signs of PCOS, such as excess androgen, followed by insulin resistance among the PCOS individuals. Given the versatile association of AMH with PCOS and scarcity in literature explaining the underling mechanisms how AMH relates with PCOS, this review article will discuss the roles of AMH in the pathogenesis of PCOS which may introduce a new era in treatment approach of PCOS.
ISSN:1110-5690
2090-3251
DOI:10.1186/s43043-022-00123-5