High dose letrozole in infertile women with unilateral tubal block: a preliminary report

Background Till now, there is no universal agreement on the best management of women with unilateral blocked tube. The aim of this study was to evaluate the use of high dose letrozole in infertile women with one blocked tube. This prospective non-randomized study was conducted at a university-affili...

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Published in:Middle East Fertility Society Journal 2021-08, Vol.26 (1), p.1-3
Main Author: Al-Hussaini, Tarek K
Format: Article
Language:English
Subjects:
Birth rate
Consent
Developing countries
Endometrium
English literature
Ethics
Fallopian tube
Genetic disorders
Infertility
IVF/ICSI
Laparoscopy
Laparotomy
LDCs
Letrozole
Ovaries
Ovulation
Patients
Pelvic inflammatory disease
Pregnancy
Sexually transmitted diseases
STD
Systematic review
Unilateral tubal block
Women
Womens health
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description Background Till now, there is no universal agreement on the best management of women with unilateral blocked tube. The aim of this study was to evaluate the use of high dose letrozole in infertile women with one blocked tube. This prospective non-randomized study was conducted at a university-affiliated infertility unit. It included 15 women with one blocked tube (proximal or mid segmental block) with a period of 1-6 years of infertility. Letrozole (10 mg/day for 5 days) was prescribed for all of them for a maximum of three cycles. The primary outcome was Live birth rate. Results Nine out of the 15 women conceived (60%). Live birth rate was 53% (8/15). All women had a good response to this regimen. None complained of side effects of this dose. No multiple pregnancies and/or congenital anomalies were reported. Conclusions This preliminary report showed that treatment of infertile women, with unilateral tubal block, with high dose letrozole is effective. To our knowledge, this is the first report in the English literature on the use of high dose of letrozole in such cases.
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The aim of this study was to evaluate the use of high dose letrozole in infertile women with one blocked tube. This prospective non-randomized study was conducted at a university-affiliated infertility unit. It included 15 women with one blocked tube (proximal or mid segmental block) with a period of 1-6 years of infertility. Letrozole (10 mg/day for 5 days) was prescribed for all of them for a maximum of three cycles. The primary outcome was Live birth rate. Results Nine out of the 15 women conceived (60%). Live birth rate was 53% (8/15). All women had a good response to this regimen. None complained of side effects of this dose. No multiple pregnancies and/or congenital anomalies were reported. Conclusions This preliminary report showed that treatment of infertile women, with unilateral tubal block, with high dose letrozole is effective. 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subjects Birth rate
Consent
Developing countries
Endometrium
English literature
Ethics
Fallopian tube
Genetic disorders
Infertility
IVF/ICSI
Laparoscopy
Laparotomy
LDCs
Letrozole
Ovaries
Ovulation
Patients
Pelvic inflammatory disease
Pregnancy
Sexually transmitted diseases
STD
Systematic review
Unilateral tubal block
Women
Womens health
title High dose letrozole in infertile women with unilateral tubal block: a preliminary report
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