Long non-coding RNA panel as a molecular biomarker in glioma

Background Glioma is one of the most malignant brain tumors, accounting for about half of the gliomas that occur in central nervous system (CNS), originates from the glial tissue of the brain. The aim of the present study was to determine the expression levels of 5 lncRNAs (MDC1-AS1, HOXA11-AS, MALA...

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Bibliographic Details
Published in:Journal of Egyptian National Cancer Institute 2021-10, Vol.33 (1), p.1-6
Main Authors: Ebrahimi, Abdol Ali, Ashoori, Hasan, Vahidian, Farnaz, Mosleh, Iman Samiei, Kamian, Shaghayegh
Format: Article
Language:English
Subjects:
Analysis
Apoptosis
Biomarkers
Brain cancer
Brain neoplasm
Brain tumors
Clinical outcomes
Epigenetics
Gene expression
Genes
Glioma
Gliomas
Medical prognosis
Pathogenesis
Prognosis
RNA
RNA, Long noncoding
Surgery
Tumorigenesis
Tumors
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Summary:Background Glioma is one of the most malignant brain tumors, accounting for about half of the gliomas that occur in central nervous system (CNS), originates from the glial tissue of the brain. The aim of the present study was to determine the expression levels of 5 lncRNAs (MDC1-AS1, HOXA11-AS, MALAT1, CASC2, ADAMTS9-AS2) in patients with high-grade glioma in comparison with low grade glioma. Methods This was a retrospective study which determined molecular biomarker on pathologic glioma samples. We examined 100 patients' pathologic block which consisted of 50 pathology samples of high-grade glioma (case group) and control group consisted of 50 pathology samples of low-grade glioma. This research was performed using real time polymerase chain reaction (PCR) technique. Results The results showed that the expression of ADAMTS9-AS2 and HOXA11-AS genes significantly increased with increasing tumor grade. Also the expression of CASC2 gene significantly decreased with increasing tumor grade. Conclusions It was concluded that ADAMTS9-AS2 and HOXA11-AS and CASC2 are promising lncRNA markers in prognosis of glioma.
ISSN:1110-0362
2589-0409
DOI:10.1186/s43046-021-00090-4