Localized Wilms' tumor in low-middle-income countries : how can we get better?

Background Wilms' tumor (WT) represents about 6% of all childhood cancers. The overall survival markedly improved to exceed 90% in developed countries, yet some studies from developing counties still have poorer outcomes. The aim of this study is to assess the clinical outcome and the different...

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Bibliographic Details
Published in:Journal of Egyptian National Cancer Institute 2020-08, Vol.32 (1), p.1-12
Main Authors: Asfour, Hosam Y, Khalil, Sahar A, Zakaria, Al-Shimaa, Ashraf, El-Sayed, Zekri, Wael
Format: Article
Language:English
Subjects:
Abdomen
Biopsy
Cancer
Chemotherapy
Egypt
Hematuria
Histology
Loco-regional
Lymphatic system
Medical prognosis
Metastasis
Oncology, Experimental
Outcome
Pathology
Patients
Pediatric
Pediatrics
Radiation therapy
Tumors
Vincristine
Wilms’ tumor
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Summary:Background Wilms' tumor (WT) represents about 6% of all childhood cancers. The overall survival markedly improved to exceed 90% in developed countries, yet some studies from developing counties still have poorer outcomes. The aim of this study is to assess the clinical outcome and the different prognostic factors that influence the outcome of pediatric loco-regional WT cases treated at National Cancer Institute (NCI), Cairo University, Egypt. This is a retrospective study which included pediatric loco-regional WT patients presented between January 2008 and December 2017. Patients were followed up till June 2019. Results Ninety-two eligible patients were included. Median age was 3 years (range 1 month-9 years). Abdominal mass was the commonest presentation (72.8%). The 5-year EFS and OS of the whole group was 83.7% and 94.6% retrospectively. Despite having a similar EFS (84.8 vs. 82.6%), stage III patients had a significantly lower OS than those in stages I and II (89.1% vs. 100%, p value 0.024). Twelve patients had unfavorable histology and had a significantly lower EFS and OS than the patients with favorable histology (50 and 83.3% vs. 88.8 and 96.3%, p value < 0.001 and 0.043, respectively). Conclusion Loco-regional Wilms' tumor cases treated in Egypt had OS nearly the same as in developed countries, but had a lower EFS than expected mainly stages I and II. The stage and histological type are the main factors influencing the survival, and further studies are needed to investigate nuclear unrest grades and proper management of such cases.
ISSN:1110-0362
2589-0409
DOI:10.1186/s43046-020-00043-3