Antibiotic‐Derived Radiotracers for Positron Emission Tomography: Nuclear or “Unclear” Infection Imaging?

The excellent features of non‐invasive molecular imaging, its progressive technology (real‐time, whole‐body imaging and quantification), and global impact by a growing infrastructure for positron emission tomography (PET) scanners are encouraging prospects to investigate new concepts, which could tr...

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Bibliographic Details
Published in:Angewandte Chemie 2022-11, Vol.134 (45), p.n/a
Main Authors: Gouws, Arno Christiaan, Kruger, Hendrik Gerhardus, Gheysens, Olivier, Zeevaart, Jan Rijn, Govender, Thavendran, Naicker, Tricia, Ebenhan, Thomas
Format: Article
Language:English
Subjects:
antibiotic-derived PET
Antibiotics
Chemistry
Emission analysis
Emissions
imaging of infection
Infectious diseases
Medical imaging
Pharmaceuticals
Positron emission
Positron emission tomography
Radioactive tracers
Radiochemistry
Radioisotopes
radiolabeling
radiotracers
Tomography
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Summary:The excellent features of non‐invasive molecular imaging, its progressive technology (real‐time, whole‐body imaging and quantification), and global impact by a growing infrastructure for positron emission tomography (PET) scanners are encouraging prospects to investigate new concepts, which could transform clinical care of complex infectious diseases. Researchers are aiming towards the extension beyond the routinely available radiopharmaceuticals and are looking for more effective tools that interact directly with causative pathogens. We reviewed and critically evaluated (challenges or pitfalls) antibiotic‐derived PET radiopharmaceutical development efforts aimed at infection imaging. We considered both radiotracer development for infection imaging and radio‐antibiotic PET imaging supplementing other tools for pharmacologic drug characterization; overall, a total of 20 original PET radiotracers derived from eleven approved antibiotics. This Review provides summary and critical evaluation, including the challenges and pitfalls, of antibiotic‐derived positron emission tomographic radiopharmaceutical development efforts aimed at infection imaging either considered for radiotracer development for infection imaging or radio‐antibiotic PET imaging supplementing other tools for pharmacologic drug characterization.
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.202204955