Early Functional Changes in Rat Arteries and Microcirculatory Vessels while Modeling Metabolic Syndrome

Early changes in the cardiovascular system of young Wistar rats were studied in modeling metabolic syndrome by a fructose load. It was found that despite some weight loss in rats fed a fructose diet, as compared to control animals, these animals showed the signs of metabolic syndrome: hyperglycemia,...

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Bibliographic Details
Published in:Journal of evolutionary biochemistry and physiology 2022-09, Vol.58 (5), p.1471-1481
Main Authors: Tsareva, I. A., Ivanova, G. T., Lobov, G. I.
Format: Article
Language:English
Subjects:
Animal Physiology
Arteries
Biochemistry
Biomedical and Life Sciences
Body weight loss
Calcium channels
Calcium conductance
Cardiovascular system
Dyslipidemia
Endothelium
Evolutionary Biology
Experimental Papers
Fructose
Guanylate cyclase
Hyperglycemia
Insulin
Insulin resistance
Life Sciences
Metabolic syndrome
Phenylephrine
Potassium channels (calcium-gated)
Potassium conductance
Smooth muscle
Sympathetic nervous system
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Summary:Early changes in the cardiovascular system of young Wistar rats were studied in modeling metabolic syndrome by a fructose load. It was found that despite some weight loss in rats fed a fructose diet, as compared to control animals, these animals showed the signs of metabolic syndrome: hyperglycemia, insulin resistance, dyslipidemia, increased activity of the sympathetic nervous system, arterial hypertension. Changes in the mesenteric arteries included an increase in the reactivity to phenylephrine and a decrease in acetylcholine-induced dilation due to decreased NO production by the endothelium, which is to a certain extent compensated by an increased production of the endothelium-derived hyperpolarizing factor realizing its effects through the activation of intermediate-conductance Ca 2+ -activated K + -channels. Fructose load led to the inhibition of soluble guanylate cyclase in arterial smooth muscle cells. In the skin microcirculatory bed of fructose-loaded rats, perfusion remained at the level typical for control animals, while skin microvessels showed an increase in neurogenic tone and an attenuation of endothelium-dependent tone. A decreased endothelial NO production was found in microcirculatory vessels, which was compensated by the synthesis of other endothelium-derived vasodilating factors.
ISSN:0022-0930
1608-3202
DOI:10.1134/S0022093022050179