The potential activity of biosynthesized silver nanoparticles of Pseudomonas aeruginosa as an antibacterial agent against multidrug-resistant isolates from intensive care unit and anticancer agent

Background Antibiotic resistance is a global problem; especially the multidrug-resistant bacteria are a serious and fatal problem in the intensive care unit. Interestingly, biosynthesized silver nanoparticles are the promising key to eliminate these microbes. Using Pseudomonas aeruginosa supernatant...

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Bibliographic Details
Published in:Environmental sciences Europe 2022-12, Vol.34 (1), p.109, Article 109
Main Authors: Abeer Mohammed, A. B., Abd Elhamid, Mona Mohamed, Khalil, Magdy Kamal Mohammed, Ali, Abdallah Soubhy, Abbas, Rateb Nabil
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotic resistance
Antibiotics
Anticancer properties
Antitumor agents
Bacteria
Biosynthesis
Earth and Environmental Science
Ecotoxicology
Environment
Fourier transforms
Hepatocellular carcinoma
Infrared spectroscopy
Intensive care
Liver cancer
Microorganisms
Minimum inhibitory concentration
Multidrug resistance
Multidrug resistant organisms
Nanoparticles
Pollution
Pseudomonas aeruginosa
Silver
Spectrum analysis
Ultraviolet spectroscopy
X-ray spectroscopy
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Summary:Background Antibiotic resistance is a global problem; especially the multidrug-resistant bacteria are a serious and fatal problem in the intensive care unit. Interestingly, biosynthesized silver nanoparticles are the promising key to eliminate these microbes. Using Pseudomonas aeruginosa supernatant is an easy and cheap method in silver nanoparticle biosynthesis. The biosynthesis conditions were adjusted, and the profiling of the biosynthesized silver nanoparticles was confirmed. Results The UV spectroscopy at a wavelength at 400 nm was 0.539 A.U., transmission electron microscope showed nanoparticles were homogeneous with a square and spherical shape, its average size 20 nm, The capping material and the existence of silver nanoparticles were confirmed using Fourier transform infrared spectroscopy, and energy dispersive X -ray spectroscopy. The minimum inhibitory concentration was 1 mg/ml against multidrug-resistant bacteria, and LC50 was 62.307 μg/ml on the hepatocellular carcinoma cell line. Conclusions Microbial-synthesized silver nanoparticles have a potential application to combat multidrug-resistant bacteria, especially in the intensive care unit.
ISSN:2190-4707
2190-4715
DOI:10.1186/s12302-022-00684-2