Antimicrobial and antibiofilm activities and bovine serum albumin binding properties of benzimidazolium derivative NHC salts and their Ag(I)‐NHC complexes

Benzimidazole type N‐heterocyclic carbene molecules and their metal complexes have well‐known biological activity. Elemental silver and silver complexes also have antibacterial and antifungal activity. In this study, silver complexes with 1‐allyl 5,6‐dimethylbenzimidazolium derivative ligands were a...

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Bibliographic Details
Published in:Applied organometallic chemistry 2022-12, Vol.36 (12), p.n/a
Main Authors: Çelik, Cem, Üstün, Elvan, Şahin, Neslihan, Tutar, Uğur
Format: Article
Language:English
Subjects:
benzimidazoles
Binding
biofilm activity
Biological activity
BSA binding
Carbenes
Cattle
Chemistry
Coordination compounds
fluorescence spectroscopy
Fungicides
In vitro methods and tests
Molecular docking
Serum albumin
Silver compounds
Spectrophotometry
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Summary:Benzimidazole type N‐heterocyclic carbene molecules and their metal complexes have well‐known biological activity. Elemental silver and silver complexes also have antibacterial and antifungal activity. In this study, silver complexes with 1‐allyl 5,6‐dimethylbenzimidazolium derivative ligands were analyzed for their antimicrobial and antibiofilm activities. Additionally, bovine serum albumin (BSA) binding properties of the molecules were analyzed by spectrophotometric methods, and the details of interactions of the molecules with BSA were investigated by molecular docking methods. While N‐heterocyclic carbene salts showed moderate antifungal and antibiofilm activity, silver complexes of these salts have strong antimicrobial activity with
ISSN:0268-2605
1099-0739
DOI:10.1002/aoc.6891