Cavity ringdown spectroscopy of nitric oxide in the ultraviolet region for human breath test

We report the spectrum of nitric oxide (NO) in the ultraviolet (UV) (225.4-227.0 nm) region based on cavity ringdown spectroscopy (CRDS). A cavity ringdown system, which consisted of a tunable UV laser source and a vacuum-pumped ringdown cavity, was constructed to measure NO at room temperature and...

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Bibliographic Details
Published in:Journal of breath research 2020-07, Vol.14 (3), p.037101-037101
Main Authors: Ai, Yukai, Li, Jing, Li, Qingyuan, Sun, Meixiu, Li, Yingxin, Wang, Chuji
Format: Article
Language:English
Subjects:
breath test
Breath tests
cavity ringdown spectroscopy
exhaled gas
nitric oxide
Spectrum analysis
Ultraviolet radiation
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Summary:We report the spectrum of nitric oxide (NO) in the ultraviolet (UV) (225.4-227.0 nm) region based on cavity ringdown spectroscopy (CRDS). A cavity ringdown system, which consisted of a tunable UV laser source and a vacuum-pumped ringdown cavity, was constructed to measure NO at room temperature and atmospheric or reduced pressure. The measured spectra were validated using LIFBase simulations. The absorption cross-section of NO at the strongest absorption peak at 226.255 nm was measured to be 7.64 × 10−18 cm2 molecule−1. Using the measured mirror reflectivity of 99.55% at 226.255 nm, the detection limit of NO was determined to be 7.4 ppb (parts per billion) based on the standard 3-σ criteria. The stability and reproducibility of this CRDS system were also tested. Furthermore, exhaled gas samples from 203 human subjects (105 healthy people and 98 lung cancer patients) were measured using the system. Results demonstrated that the cavity ringdown spectroscopy in the deep-UV region has potential for breath NO test.
ISSN:1752-7155
1752-7163
1752-7163
DOI:10.1088/1752-7163/ab8184